ArticleThe Analyst2026
Ultrasensitive SERS detection
Article in The Analyst, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Surface-enhanced Raman spectroscopy (SERS) offers a powerful platform for ultrasensitive molecular detection, yet its performance is often limited by inefficient analyte transport to plasmonic hotspots. In this work, we present a hybrid microfluidic-SERS detection platform that integrates hydrodynamic focusing and electric field-induced migration to overcome diffusion limitations and enhance molecular delivery to the sensing interface. The system employs a sheath-flow microfluidic device with a thermally evaporated silver nanostructured substrate, serving both as a SERS-active surface and as an electrochemical working electrode. Rhodamine 6G, a model organic dye, was used to evaluate performance under four flow and biasing conditions. The strongest SERS signals were achieved under combined sheath flow and -1 V electric field, demonstrating a synergistic enhancement from both physical and electrokinetic focusing mechanisms. Quantitative analysis yielded Langmuir adsorption behavior over the tested range of concentration (0.1 nM-10 μM) and a limit of detection of 0.076 nM. Mechanistic confirmation was obtained through Stark-shift measurements of 4-mercaptobenzonitrile, which exhibited a measurable blue shift in the CN vibrational mode under +5 V bias, verifying the presence of localized electric fields at the metal-solution interface. This dual-mode transport-enhancement strategy provides a robust and generalizable method for improving sensitivity and control in microfluidic SERS detection platforms, with broad potential applications in biomedical diagnostics, environmental monitoring, and trace contaminant analysis.
Identifiers
42852977What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.