Medication-related osteonecrosis of the jaw in cancer and osteoporosis patients: a retrospective seven-year single-center Norwegian cohort study of clinical profiles and documented soft tissue healing.

Safiyye Süslü, Håvard J Haugen, Tormod B Krüger, Janne Elin Reseland, Bente Brokstad Herlofson

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Article in Acta odontologica Scandinavica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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Safiyye SüslüDepartment of Biomaterials, Institute of Clinical Dentistry, University of Oslo, Oslo, Norway.

Håvard J HaugenDepartment of Biomaterials, Institute of Clinical Dentistry, University of Oslo, Oslo, Norway. haavarjh@uio.no.

Tormod B KrügerDepartment of Oral Medicine and Oral Surgery, Institute of Clinical Dentistry, University of Oslo, Oslo, Norway.

Janne Elin ReselandDepartment of Biomaterials, Institute of Clinical Dentistry, University of Oslo, Oslo, Norway.

Bente Brokstad HerlofsonDepartment of Oral Medicine and Oral Surgery, Institute of Clinical Dentistry, University of Oslo, Oslo, Norway.

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6 · The paper itself

Abstract

objectiveTo compare systemic profiles, oral findings, and documented soft tissue healing between cancer and osteoporosis patients with medication-related osteonecrosis of the jaw (MRONJ). MATERIAL AND

methodsThis retrospective single-center cohort included 105 cases treated in 2013-2019 (56 cancer; 49 osteoporosis). Healing at last follow-up was analyzed using adjusted logistic regression and Firth sensitivity analysis.

resultsOf 102 cases with known final status, 68 had documented healing. Osteoporosis cases were older, predominantly female, and had longer antiresorptive exposure than cancer cases (76.7 ± 11.1 vs. 70.0 ± 8.5 years; 102.5 ± 77.8 vs. 34.6 ± 28.5 months; both p < 0.001). Stage II predominated and Stage 0 was uncommon (3/105, 2.9%). Previous tooth extraction at the MRONJ lesion site was more frequent in osteoporosis (95.9% vs. 71.4%; p < 0.001). Surgical treatment was associated with higher healing odds (adjusted odds ratio [OR]: 11.12, 95% confidence interval [CI]: 4.12 to 33.35; p < 0.001), whereas cancer indication was associated with lower odds (adjusted OR: 0.23, 95% CI: 0.07 to 0.68; p = 0.011).

conclusionsSystemic profiles differed; oral patterns were similar. Non-random treatment and missing healing dates limit interpretation. Previous tooth extraction was the most frequent antecedent event; its indication and timing were unverified.

Indexed as

Bisphosphonate-Associated Osteonecrosis of the JawNeoplasmsOsteoporosisWound HealingAgedAged, 80 and overCohort StudiesFemaleHumansMaleNorwayRetrospective Studies

Identifiers

PMID42852807

DOI10.2340/aos.v85.46983

PMCPMC13660455

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