Evidence map›Paper›PMID 42852662›Full record

ArticleThe Kaohsiung journal of medical sciences2026

Olaparib Blocks Oxidative Stress-Dependent NLRP3 Inflammasome in Pediatric Acute Lung Injury by Metabolic Reprogramming via AMPK-Driven Autophagic Flux.

Fen Gong, Mei-Ling Yu, Zheng-Rong Chen, Mei Li, Xu Sang, Yong-Dong Yan

Abstract read
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Article in The Kaohsiung journal of medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Fen GongDepartment of Respiratory Medicine, Children's Hospital of Soochow University, Jiangsu Province, China.
Mei-Ling YuDepartment of Pharmacy, The First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui, People's Republic of China.
Zheng-Rong ChenDepartment of Respiratory Medicine, Children's Hospital of Soochow University, Jiangsu Province, China.
Mei LiPediatrics Research Institute, Children's Hospital of Soochow University, Suzhou, P. R. China.
Xu SangDeputy Chief Physician of Pediatrics, First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui, People's Republic of China.
Yong-Dong YanDepartment of Respiratory Medicine, Children's Hospital of Soochow University, Jiangsu Province, China.ORCID https://orcid.org/0009-0008-6858-5558

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pediatric acute lung injury (ALI) is a life-threatening syndrome defined by dysregulated pulmonary inflammation and impaired alveolar gas exchange, with limited therapeutic interventions. This study aims to evaluate the therapeutic efficacy and mechanistic basis of Olaparib, a clinically approved PARP inhibitor, using in vitro and in vivo models of pediatric ALI. In LPS/ATP-stimulated THP-1-derived macrophages, Olaparib induced metabolic reprogramming, as indicated by a reduced NAD

Indexed as

AMPKmetabolic reprogrammingNLRP3 inflammasomeolaparibpediatric acute lung injury

Identifiers

PMID42852662

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.