ArticleJournal of biomedical optics2026
Geometric decoupling of epidermal melanin and dermal hemoglobin signals using coaxial and spatially resolved NIRS.
Article in Journal of biomedical optics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
Significance: Epidermal melanin can confound NIRS measurements of tissue oxygen saturation and reduce accuracy across skin tones. Aim: We evaluated whether a coaxial detector can provide a superficial reference that improves absolute Approach: Monte Carlo simulations of multilayer skin were evaluated using mutual information and XGBoost regression, with entire melanin levels held out during validation. Three detector configurations were compared: coaxial only, surface only, and the combined geometry. A secondary experimental analysis examined absolute and baseline referenced oxygenation prediction using validation that excluded one recording at a time. Results: The combined coaxial plus surface detector configuration reduced average Conclusions: These findings support future experimental validation of integrated coaxial plus spatially resolved probes for melanin-robust absolute tissue oxygenation monitoring.
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