ArticleCureus2026
Effects of Early Postoperative Whey Protein Isolate-Based Oral Supplementation on Nutritional Outcomes in Patients Undergoing Coronary Artery Bypass Grafting: A Prospective Multicentre Real-World Study.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
Background Coronary artery bypass grafting (CABG) triggers inflammatory and catabolic responses, increasing the risk of postoperative nutritional deficits. Whey protein isolate (WPI) may improve recovery and muscle strength. This study evaluated the impact of early postoperative WPI-based supplementation on nutritional outcomes among CABG patients. Methodology This open-label, single-arm, prospective real-world study enrolled 200 adult patients undergoing CABG at two tertiary care centres in India. Patients received a WPI-based oral nutritional supplement starting 24-48 hours post-surgery and continued for 30 days post-discharge. Outcomes included protein and calorie adequacy, nutritional status, change in weight, hand-grip strength, safety, and patient and physician experiences with the WPI-based nutritional supplement. Data were analysed using appropriate parametric and nonparametric tests. Results Of the 200 patients enrolled, 182 (91.0%) completed the study. They were included in the intent-to-treat (ITT) group, while 119 (59.5%) adhered to the protocol, completed the 30-day follow-up visit, and were included in the per-protocol (PP) group. Compared with the day of supplement initiation (Visit 1), the proportion of patients achieving calorie and protein adequacy at the end of the study (EOS) increased significantly (calorie adequacy: ITT (
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