ArticleACS omega2026
Impact of Organic Solvents, Surfactants, and Nonfunctionalized PEGs on PEGylation Reaction Yield.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The optimization of PEGylation reaction yield is critical for the efficient production of therapeutic bioconjugates. This study systematically investigates the influence of three distinct classes of additives -organic cosolvents, nonreactive poly-(ethylene glycols) (PEGs) of varying molecular weights, and surfactants- on the conjugation efficiency of a model protein. Quantitative analysis via SDS-PAGE densitometry revealed that the addition of 40% (v/v) DMSO significantly enhanced the reaction yield compared to the aqueous control, while methanol resulted in a marked decrease in efficiency. These results were rationalized using Hansen solubility parameters, which indicated that the high dispersion cohesion (18.4 MPa
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