ArticleACS omega2026
Strontium-Doped Hydroxyapatite as a Multifunctional Platform: Tailoring Structural, Mechanical, and Drug Delivery Properties for Bone-Related Applications.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Hydroxyapatite (HAp) is a calcium phosphate ceramic that has been extensively studied for its similarity to the mineral phase of bone tissue, and it exhibits excellent biocompatibility and osteoconductivity. However, its intrinsic brittleness and low fracture resistance limit its use in load-bearing environments, motivating the use of ionic doping to enhance its properties. Doping with strontium (Sr) is particularly advantageous, as this ion is associated with bone regeneration processes, improves osteogenic response, and favorably modifies the material's lattice parameters and structural organization. In this work, Sr-doped HAp nanorods (5, 10, and 20%) were synthesized by the hydrothermal method, and their structural, mechanical, and drug delivery properties were investigated, with mechanical testing performed on non-sintered pellets to preserve the characteristics of the as-synthesized material. Drug incorporation and release assays with ciprofloxacin were conducted to evaluate the multifunctional potential for bone healing applications. The results confirmed the successful incorporation of Sr
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