ArticleRSC advances2026
A multifunctional ZIF-8@CuO/collagen-binding peptide hydrogel for photothermal-enhanced antibacterial and infected skin wound management.
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Owing to continuous bacterial proliferation, a persistent inflammatory response, and impaired vascularization, infected skin wounds remain a major clinical challenge. Herein, we fabricated a multifunctional skin-repair material by incorporating ZIF-8@CuO nanoparticles and a collagen-binding vascular endothelial growth factor mimetic peptide (C-VEGFMP) into a gelatin methacryloyl (GelMA) hydrogel. The ZIF-8@CuO nanoparticles were prepared by controllably depositing copper oxide (CuO) onto the surface of zeolitic imidazolate framework-8 (ZIF-8). ZIF-8@CuO can endowed the hydrogel with potent antibacterial and anti-inflammatory activities, as well as efficient near-infrared (NIR) photothermal conversion capability. C-VEGFMP was constructed by introducing a collagen-binding sequence into the VEGFMP. This modified peptide can stably anchor to GelMA and maintain its bioactivity at the hydrogel-tissue interface. The resulting ZIF-8@CuO/C-VEGFMP hydrogel exhibited favorable cytocompatibility, broad-spectrum antibacterial activity and prominent pro-angiogenic performance. Upon NIR irradiation, the photothermal effect of ZIF-8@CuO can synergistically eradicate pathogenic bacteria, thereby enhancing photothermal therapeutic efficacy. In addition, the sustained presence of bioactive C-VEGFMP promoted epithelial regeneration, collagen deposition, and neovascularization in infected full-thickness wounds. Transcriptomic analysis indicated that treatment with ZIF-8@CuO/C-VEGFMP under NIR irradiation exerted anti-inflammatory, pro-angiogenic and tissue-repair effects mainly by upregulating thrombomodulin (THBD) and Ets proto-oncogene 2 (Ets2) genes. This study provides a multifunctional strategy that combines nanoparticle-mediated photothermal antibacterial effects with functionalized peptides, offering a promising therapeutic modality for the management of infected skin injuries.
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