Evidence map›Paper›PMID 42852209›Full record

ArticleACS omega2026

Synthesis and Biological Evaluation of Prazosin-Derived Antitrypanosomal Agents Putatively Targeting FAZ1.

Fatma M Salem, William R Martin, Xiaotong Zhao, Tyler E Roeper, Jamie A Schuster, Andre C Martin, Ruchitha Korem, Soha M Bolbol, Grace M Weske, Sk Abdus Sayeed and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Fatma M SalemDepartment of Chemistry, Center for Gene Regulation in Health and Disease, College of Arts and Sciences, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States.
William R MartinDepartment of Chemistry, Center for Gene Regulation in Health and Disease, College of Arts and Sciences, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States.ORCID https://orcid.org/0000-0003-0616-0462
Xiaotong ZhaoDepartment of Chemistry, Center for Gene Regulation in Health and Disease, College of Arts and Sciences, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States.
Tyler E RoeperDepartment of Chemistry, Center for Gene Regulation in Health and Disease, College of Arts and Sciences, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States.ORCID https://orcid.org/0009-0004-9557-8290
Jamie A SchusterDepartment of Chemistry, Center for Gene Regulation in Health and Disease, College of Arts and Sciences, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States.
Andre C MartinDepartment of Chemistry, Center for Gene Regulation in Health and Disease, College of Arts and Sciences, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States.
Ruchitha KoremDepartment of Chemistry, Center for Gene Regulation in Health and Disease, College of Arts and Sciences, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States.
Soha M BolbolDepartment of Chemistry, Center for Gene Regulation in Health and Disease, College of Arts and Sciences, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States.
Grace M WeskeDepartment of Chemistry, Center for Gene Regulation in Health and Disease, College of Arts and Sciences, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States.
Sk Abdus SayeedDepartment of Biological, Geological and Environmental Sciences, Center for Gene Regulation in Health and Disease, College of Arts and Sciences, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States.
Afonso Santine Mm VelezDepartment of Chemistry, Center for Gene Regulation in Health and Disease, College of Arts and Sciences, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States.ORCID https://orcid.org/0000-0002-7188-833X
Wenjing ZhangDepartment of Chemistry, Center for Gene Regulation in Health and Disease, College of Arts and Sciences, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States.
Lyubomyr TurchynAnimal Research Facility, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States.
Bibo LiDepartment of Biological, Geological and Environmental Sciences, Center for Gene Regulation in Health and Disease, College of Arts and Sciences, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States.
Bin SuDepartment of Chemistry, Center for Gene Regulation in Health and Disease, College of Arts and Sciences, Cleveland State University, 2121 Euclid Avenue, Cleveland, Ohio 44115, United States.ORCID https://orcid.org/0000-0002-0711-441X

Funding

Selective tubulin inhibitors with improved cell update for kinetoplastid infectionsR15AI103889 · NIAID · CLEVELAND STATE UNIVERSITY · PI SU, BIN · 2013 to 2016
$873k
NIAID NIH HHS R15 AI103889
6 · The paper itself

Abstract

Current therapeutic interventions for Human African Trypanosomiasis (HAT) are severely limited by emerging drug resistance and profound systemic toxicity, necessitating the urgent development of novel chemotypes. Building upon our previous identification of the alpha-adrenoceptor antagonist Prazosin as a scaffold with off-target activity against

Identifiers

PMID42852209
PMCPMC13647368

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.