Evidence map›Paper›PMID 42852199›Full record

ArticleACS omega2026

Discovery of Novel Peptides as DPP-IV Inhibitors:

Burak Calis, Fernando Berton Zanchi, Beyza Canakcimaksutoglu, Ahmet E Yetiman, Ozkan Fidan

Abstract read
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Burak CalisDepartment of Bioengineering, Graduate School, Abdullah Gul University, Kayseri, Türkiye 38080.
Fernando Berton ZanchiBioinformatic and Medicinal Chemistry Laboratory, Fiocruz/RO, Porto Velho, Rondonia Brazil 76812-245.ORCID https://orcid.org/0000-0003-3386-0069
Beyza CanakcimaksutogluDepartment of Bioengineering, Graduate School, Abdullah Gul University, Kayseri, Türkiye 38080.ORCID https://orcid.org/0009-0007-3496-6371
Ahmet E YetimanDepartment of Food Engineering, Faculty of Engineering, Erciyes University, Kayseri, Türkiye 38030.
Ozkan FidanDepartment of Bioengineering, Faculty of Life and Natural Sciences, Abdullah Gul University, Kayseri, Türkiye 38080.ORCID https://orcid.org/0000-0001-5312-4742

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type 2 diabetes mellitus (T2DM) is the most common metabolic disorder characterized by impaired insulin secretion, which leads to obesity. The incretin hormone glucagon-like peptide-1 (GLP-1) has a significant role in glucose homeostasis, but its native form in the human body is highly susceptible to proteolytic degradation by dipeptidyl peptidase IV (DPP-IV). In this study, a peptide library was constructed from antimicrobial peptide databases to discover novel DPP-IV inhibitors based on structural similarity to that of native GLP-1. A total of 26 candidate peptides were shortlisted and screened using

Identifiers

PMID42852199
PMCPMC13647329

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.