Evidence map›Paper›PMID 42852183›Full record

ArticleBrain disorders (Amsterdam, Netherlands)2026

Parietal and prefrontal transcranial magnetic stimulation (TMS) for mild cognitive impairment (MCI): A pilot randomized clinical trial.

Joy L Taylor, Beatriz Hernandez, Laura C Lazzeroni, M Windy McNerney, Alesha Heath, J Wesson Ashford, Jauhtai Joseph Cheng, Steven Chao, Priyanka Bhatt, Michael Iv and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain disorders (Amsterdam, Netherlands), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Joy L TaylorSierra-Pacific Mental Illness Research Education Clinical Center (MIRECC), US Department of Veterans Affairs (VA) Palo Alto Health Care System, Palo Alto, CA, 94304, USA.ORCID 0000-0002-5776-3995
Beatriz HernandezSierra-Pacific Mental Illness Research Education Clinical Center (MIRECC), US Department of Veterans Affairs (VA) Palo Alto Health Care System, Palo Alto, CA, 94304, USA.
Laura C LazzeroniSierra-Pacific Mental Illness Research Education Clinical Center (MIRECC), US Department of Veterans Affairs (VA) Palo Alto Health Care System, Palo Alto, CA, 94304, USA.
M Windy McNerneySierra-Pacific Mental Illness Research Education Clinical Center (MIRECC), US Department of Veterans Affairs (VA) Palo Alto Health Care System, Palo Alto, CA, 94304, USA.
Alesha HeathSierra-Pacific Mental Illness Research Education Clinical Center (MIRECC), US Department of Veterans Affairs (VA) Palo Alto Health Care System, Palo Alto, CA, 94304, USA.
J Wesson AshfordDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Jauhtai Joseph ChengSierra-Pacific Mental Illness Research Education Clinical Center (MIRECC), US Department of Veterans Affairs (VA) Palo Alto Health Care System, Palo Alto, CA, 94304, USA.
Steven ChaoSierra-Pacific Mental Illness Research Education Clinical Center (MIRECC), US Department of Veterans Affairs (VA) Palo Alto Health Care System, Palo Alto, CA, 94304, USA.
Priyanka BhattSierra-Pacific Mental Illness Research Education Clinical Center (MIRECC), US Department of Veterans Affairs (VA) Palo Alto Health Care System, Palo Alto, CA, 94304, USA.
Michael IvDepartment of Radiology, Division of Neuroimaging and Neurointervention, Stanford University Medical Center, Stanford, CA, 94305, USA.
Fatemeh S MojabiSierra-Pacific Mental Illness Research Education Clinical Center (MIRECC), US Department of Veterans Affairs (VA) Palo Alto Health Care System, Palo Alto, CA, 94304, USA.
Jerome A YesavageSierra-Pacific Mental Illness Research Education Clinical Center (MIRECC), US Department of Veterans Affairs (VA) Palo Alto Health Care System, Palo Alto, CA, 94304, USA.

Funding

Noninvasive Cortical Stimulation to Improve Memory in Mild Cognitive ImpairmentR01AG055526 · NIA · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI TAYLOR, JOY L · 2017 to 2021
$1.3M
BLRD VA IK2 BX004105NIA NIH HHS R01 AG055526
6 · The paper itself

Abstract

Background: Even though studies of repetitive transcranial magnetic stimulation (rTMS) have demonstrated improvements in cognitive function, we know little about what site of stimulation would be ideal for improving memory. Methods: We investigated two sites: (1) the dorsolateral prefrontal cortex (DLPFC); and (2) the lateral parietal cortex (LPC), a more novel site. Forty amnestic MCI participants were randomized to one of three rTMS groups: (1) active DLPFC; (2) active LPC; and (3) sham. After completing 20 sessions of MRI-neuronavigated, bilateral rTMS, the participants were followed for 6 months. The primary outcome/endpoint was the California Verbal Learning Test-II (CVLT-II) list learning score assessed at 1-week post intervention. Results: Thirty-seven of 40 randomized participants provided primary endpoint data. Compared with the sham group, the active LPC group performed significantly higher on CVLT-II list learning ( Conclusion: The parietal cortex is a promising TMS target for improving memory function in MCI. More definitive trials are needed to compare the efficacy of parietal and DLPFC TMS for treatment of memory and cognitive impairment.

Indexed as

Alzheimer’s diseaseMemoryMild cognitive impairmentParietal cortexPrefrontal cortexTranscranial magnetic stimulation

Identifiers

PMID42852183
PMCPMC13649325

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.