Evidence map›Paper›PMID 42852172›Full record

ReviewAllergologie select2026

Comparison between as-needed versus regular treatment for allergic rhinitis: Protocol for a systematic review.

Catarina Ferreira, Vítor Henrique Duarte, Nicky Akbarian, Antonio Bognanni, Sara Gil-Mata, Ana Margarida Pereira, Manuel Marques-Cruz, Torsten Zuberbier, Holger J Schünemann, João A Fonseca and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Allergologie select, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Catarina FerreiraMEDCIDS - Department of Community Medicine, Information and Health Decision Sciences.
Vítor Henrique DuarteMEDCIDS - Department of Community Medicine, Information and Health Decision Sciences.
Nicky AkbarianFaculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Antonio BognanniClinical Epidemiology and Research Center (CERC), IRCCS Humanitas Research Hospital & Department of Biomedical Sciences, Humanitas University, Milan, Italy.
Sara Gil-MataMEDCIDS - Department of Community Medicine, Information and Health Decision Sciences.
Ana Margarida PereiraMEDCIDS - Department of Community Medicine, Information and Health Decision Sciences.
Manuel Marques-CruzMEDCIDS - Department of Community Medicine, Information and Health Decision Sciences.
Torsten ZuberbierInstitute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin.
Holger J SchünemannClinical Epidemiology and Research Center (CERC), IRCCS Humanitas Research Hospital & Department of Biomedical Sciences, Humanitas University, Milan, Italy.
João A FonsecaMEDCIDS - Department of Community Medicine, Information and Health Decision Sciences.
Jean BousquetInstitute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin.
Rafael José VieiraMEDCIDS - Department of Community Medicine, Information and Health Decision Sciences.
Bernardo Sousa-PintoMEDCIDS - Department of Community Medicine, Information and Health Decision Sciences.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAllergic rhinitis (AR) impairs quality of life. While most trials assess regular regimen medication use, mobile-Health (mHealth) data suggest that most patients use treatments on an as-needed basis.

objectivesProtocol for a systematic review comparing as-needed versus regular AR treatment regimens regarding efficacy and safety. MATERIALS AND

methodsWe will conduct a systematic review and network meta-analysis (NMA) of randomized controlled trials involving patients of any age with perennial or seasonal AR. Oral and intranasal drugs will be compared in an as-needed regimen versus a regular regimen or placebo. Primary outcomes will be the Total Nasal Symptom Score, the Total Ocular Symptom Score, and the Rhinoconjunctivitis Quality-of-Life Questionnaire.

conclusionThis review will evaluate the efficacy and safety of two different strategies for AR management. The findings of this review will inform the Allergic Rhinitis and its Impact on Asthma (ARIA) 2024-2025 guidelines.

Indexed as

allergic rhinitisantihistaminesas-needed treatmentintranasal corticosteroids

Identifiers

PMID42852172
PMCPMC13647244

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.