ArticleAllergologie select2026
Species-specific outcomes in wasp sting challenges during venom immunotherapy and their respective follow-up.
Article in Allergologie select, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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12 authors.
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Abstract
backgroundInsect venom allergy is a major cause of life-threatening anaphylaxis, with venom immunotherapy (VIT) being the gold standard for prevention. Sting challenges (SC) are used to assess immune tolerance and VIT efficacy, but factors influencing outcomes remain unclear. This study examined whether the stinging insect species affects SC outcomes during VIT and evaluated outcomes during long-term follow-up. MATERIALS AND
methodsA retrospective analysis of 1,163 patients undergoing SC during wasp venom VIT was performed. The stinging species was entomologically confirmed. Associations between SC tolerance and species, skin prick test (SPT) results, venom-specific IgE levels, and treatment duration were analyzed using multivariable logistic regression adjusted for demographics. Follow-up assessed subsequent field stings and systemic reactions.
resultsSCs were conducted with
conclusionSpecies-specific differences influence sting challenge outcomes, suggesting incomplete cross-protection of
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