ArticleFrontiers in genetics2026
Bridging bone and muscle: ontology-driven prioritization of candidate genes at the osteoporosis-sarcopenia interface by gene ontology reverse lookup.
Article in Frontiers in genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Osteosarcopenia reflects the co-occurrence of osteoporosis and sarcopenia, but the molecular processes shared between impaired bone and muscle homeostasis remain incompletely characterized. This study applied a transparent, hypothesis-generating annotation-based framework to prioritize candidate genes at the osteoporosis-sarcopenia interface. Methods: GOReverseLookup was applied to manually curated Gene Ontology term sets representing biological mechanisms relevant to osteoporosis and sarcopenia. A curated set of 367 GO terms representing key disease mechanisms served as input. Using Fisher's exact testing with Benjamini-Hochberg correction and predefined ortholog-propagation settings incorporating Results: The primary analysis identified 37 candidate genes meeting the predefined significance criterion for both osteoporosis- and sarcopenia-related states of interest. The analysis highlighted a subset of less-characterized candidates, including Conclusion: GOReverseLookup generated a transparent, annotation-based candidate list for investigating shared osteoporosis- and sarcopenia-related mechanisms. These findings should be interpreted as hypothesis-generating prioritization results requiring independent experimental and clinical validation.
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