ArticleFrontiers in oral health2026
Comparative efficacy of Clinpro
Article in Frontiers in oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
4 authors.
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Abstract
Introduction: Fixed orthodontic appliances increase plaque accumulation and the risk of enamel white spot lesions (WSLs). Although Duraphat™ Varnish (22,600 ppm fluoride) is widely used for WSLs management, limited evidence exists regarding the remineralization efficacy of the newer Clinpro™ Clear Fluoride Treatment (9,500 ppm fluoride). Objective: To compare the remineralization efficacy of Duraphat™ Varnish, single-application Clinpro™ Clear, double-application Clinpro™ Clear, and a no-treatment control on artificial WSLs adjacent to orthodontic brackets. Methods: Sixty-eight extracted human premolars were randomly allocated to four groups ( Results: Duraphat™ Varnish demonstrated significantly greater hardness recovery than single-application Clinpro™ Clear ( Conclusion: Under the present
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