SynthesisFrontiers in neuroscience2026
Multicomponent non-pharmacological interventions for preventing delirium in critically ill patients: a systematic review and meta-analysis of randomized controlled trials.
Synthesis in Frontiers in neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
5 authors.
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Abstract
Background: It is necessary to evaluate the efficacy of multicomponent non-pharmacological interventions in preventing and managing intensive care unit (ICU) delirium and identify the most effective intervention combinations. Methods: A systematic literature search was conducted in PubMed, EMBASE, CINAHL, Cochrane Library, and ProQuest Dissertations and Theses A&I databases from inception to July 3, 2026, supplemented by a hand search of prior meta-analyses. Only randomized trials were included. Meta-analysis was performed using risk ratios (RR) or mean differences (MD) with 95% confidence intervals (CI). Random-effects models with restricted maximum likelihood estimation and modified Hartung-Knapp confidence intervals were used. Risk of bias was assessed using the Cochrane risk-of-bias tool for randomized controlled trials. The certainty of evidence was assessed using the GRADE approach. Results: The search identified 13 randomized controlled trials encompassing 5,525 patients. Multicomponent interventions significantly reduced delirium incidence (RR 0.53, 95% CI [0.36, 0.76], I Conclusion: This study demonstrated that multi-component interventions effectively reduce delirium incidence in critically ill patients. The evidence did not establish that one component combination was superior to another. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42024592821.
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