ArticleCase reports in endocrinology2026
Persistent Hyperinsulinemic Hypoglycemia After Insulinoma Surgery: Diagnostic Impact of GLP-1 Receptor PET/CT After Negative Conventional Imaging.
Article in Case reports in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Localization of recurrent or residual insulinoma may be particularly challenging in postoperative setting, especially in the presence of postoperative anatomical distortion and inconclusive conventional imaging. Case Presentation: A 71-year-old man developed recurrent endogenous hyperinsulinemic hypoglycemia following apparently curative surgical enucleation of a pancreatic insulinoma. The postoperative course was complicated by intra-abdominal hemorrhage and pseudocyst formation, resulting in marked anatomical distortion. Despite persistent biochemical evidence of insulinoma recurrence, serial contrast-enhanced computed tomography (CT) and Conclusion: This case highlights the clinical value of GLP-1 receptor PET/CT for localizing insulinoma in the context of negative conventional or somatostatin receptor (SSTR)-based imaging. Accurate functional localization may directly guide minimally invasive therapeutic interventions and help avoid high-risk reoperative pancreatic surgery.
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