Evidence map›Paper›PMID 42852101›Full record

ArticleNpj structural biology2026

Mechanism of activation of an ancestral TEC kinase by PIP

Eva Krötenheerdt, Lucas Piëch, Freia von Raußendorf, Ronja Reinhardt, Ranjana Nataraj, Nicholas Wedige, Hunter G Nyvall, Emma E Walsh, John E Burke, Thomas A Leonard

Abstract read
In one paragraph

Article in Npj structural biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Eva KrötenheerdtMax Perutz Labs, Medical University of Vienna, Vienna, Austria.
Lucas PiëchMax Perutz Labs, Medical University of Vienna, Vienna, Austria.
Freia von RaußendorfMax Perutz Labs, Medical University of Vienna, Vienna, Austria.
Ronja ReinhardtMax Perutz Labs, Medical University of Vienna, Vienna, Austria.
Ranjana NatarajMax Perutz Labs, Medical University of Vienna, Vienna, Austria.
Nicholas WedigeBioOptics Light Microscopy Facility, Max Perutz Labs, Vienna, Austria.
Hunter G NyvallDepartment of Biochemistry and Microbiology, University of Victoria, Victoria, BC Canada.
Emma E WalshDepartment of Biochemistry and Microbiology, University of Victoria, Victoria, BC Canada.
John E BurkeDepartment of Biochemistry and Microbiology, University of Victoria, Victoria, BC Canada.
Thomas A LeonardMax Perutz Labs, Medical University of Vienna, Vienna, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The TEC kinases are a family of five paralogous mammalian genes that play crucial roles in cell growth, proliferation, and differentiation, particularly in immune cells. The recruitment and activation of the TEC kinases depend on the generation of the lipid second messenger, PIP

Indexed as

Cell biologyMolecular biology

Identifiers

PMID42852101
PMCPMC13648279

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.