ArticleEuropean heart journal open2026
Polyamines, cardiorespiratory fitness, body composition, and mitochondrial function in older patients with coronary artery disease.
Article in European heart journal open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Aims: Higher dietary spermidine intake has been associated with lower cardiovascular mortality. Spermidine and spermine support cellular homeostasis and mitochondrial function across species, but their relevance to physical and mitochondrial function in humans remains unclear. We examined associations of dietary spermidine and circulating and skeletal muscle spermidine and spermine with physical performance, body composition, and mitochondrial respiratory capacity in older patients with coronary artery disease. Methods and results: We included 187 patients with coronary artery disease [median age 72 (68-76) years; 80% men; 95% with prior coronary revascularization]. The primary outcomes were peak oxygen uptake and appendicular lean mass. Each doubling of dietary spermidine intake was associated with higher peak oxygen uptake (β 2.6 mL·kg Conclusion: These observational findings warrant randomized trials to determine whether dietary spermidine interventions may influence physical and mitochondrial function in older patients with coronary artery disease.
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