ReviewFrontiers in nutrition2026
Next-generation bio-packaging systems for food safety and shelf-life extension: controlled-release antimicrobial strategies and migration control.
Review in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Next-generation bio-packaging systems employ controlled-release antimicrobial and antioxidant strategies to enhance food preservation while limiting premature depletion of active compounds. Biopolymer matrices and nano-enabled architectures regulate bioactive release through diffusion pathways, encapsulation domains, crystallinity, and matrix organization, thereby influencing preservation efficacy, migration behavior, and food-contact safety. Recent advances demonstrate the effectiveness of engineered antimicrobial systems in controlling microbial proliferation during storage. Hybrid ZnO/graphene oxide/montmorillonite coatings have achieved approximately 60% inhibition of gram-positive and gram-negative microorganisms, highlighting the potential of nano-enabled architectures for sustained antimicrobial protection. Intelligent sensing technologies further support real-time monitoring of freshness and spoilage. Applications across meat, seafood, dairy, fresh produce, bakery, and ready-to-eat foods demonstrate improved shelf life, quality retention, and food safety. Biodegradable materials, renewable feedstocks, and circular-economy compatibility further strengthen the sustainability of these systems. This review examines controlled-release mechanisms, antimicrobial and antioxidant functionalities, intelligent sensing technologies, migration behavior, safety assessment, sustainability considerations, and regulatory perspectives within a unified framework for next-generation bio-packaging systems. Interactions among material structure, bioactive delivery, antimicrobial efficacy, migration characteristics, and food-contact safety determine the performance and application of emerging bio-based packaging technologies. This review integrates controlled-release design, antimicrobial performance, migration control, and food-contact safety to evaluate emerging nano-enabled bio-packaging systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.