ArticleCurrent geriatrics reports2025
Clinically Meaningful or Just Measurable? What Physiologic Outcomes Tell Us About Aging Interventions.
Article in Current geriatrics reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Authors and funding
6 authors.
Funding
Abstract
Purpose of review: As the aging population grows, identifying interventions that meaningfully improve physiologic health is increasingly important. This review examines recent evidence (2019-2025) on exercise, nutrition, pharmacologic, and multimodal interventions aimed at preserving function and extending healthspan in adults aged ≥65 years. Recent findings: Exercise and protein supplementation-particularly when combined-consistently improve muscle strength, mobility, and cardiovascular fitness. Multidomain lifestyle programs delay disability and enhance physical function. Novel approaches, including pharmaconutrition, senolytics, and stem cell therapies, target aging processes such as inflammation, cellular senescence, and sarcopenia. These early-phase interventions show promise for improving strength, reducing frailty, and potentially slowing biological aging. Summary: Targeted interventions can improve physiologic outcomes and functional status in older adults. Lifestyle strategies remain foundational, while emerging geroscience-based therapies may offer additive benefits. Future research should clarify optimal combinations, timing, and patient selection to guide personalized, integrative approaches to healthy aging.
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