Evidence map›Paper›PMID 42851917›Full record

ArticleACS catalysis2026

DiploPhos: A Hemilabile Bisphosphine for Sterically Hindered Ni-Catalyzed Suzuki-Miyaura Couplings.

T Judah Raab, Hang Chi Ho, Tyler Kerr, Nari Tao, Shashank Shekhar, Rafal Swiatowiec, Michael C Haibach, Abigail G Doyle

Abstract read
In one paragraph

Article in ACS catalysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

T Judah RaabDepartment of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, California 90095, United States.ORCID 0000-0001-9449-5574
Hang Chi HoDepartment of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, California 90095, United States.ORCID 0009-0009-7816-3436
Tyler KerrDepartment of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, California 90095, United States.
Nari TaoDepartment of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, California 90095, United States.
Shashank ShekharProcess Chemistry, AbbVie Inc. North Chicago, Illinois 60064, United States.ORCID 0000-0002-1903-5380
Rafal SwiatowiecProcess Chemistry, AbbVie Inc. North Chicago, Illinois 60064, United States.ORCID 0009-0002-8311-5913
Michael C HaibachProcess Chemistry, AbbVie Inc. North Chicago, Illinois 60064, United States.ORCID 0000-0001-8383-5633
Abigail G DoyleProcess Chemistry, AbbVie Inc. North Chicago, Illinois 60064, United States.ORCID 0000-0002-6641-0833

Funding

New Directions in Nickel and Photoredox CatalysisR35GM126986 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Abigail Gutmann Doyle · 2018 to 2026
$3.7M
NMR Console and Prodigy CryoProbeS10OD028644 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GARG, NEIL K · 2021 to 2021
$600k
NIGMS NIH HHS R35 GM126986NIH HHS S10 OD028644
6 · The paper itself

Abstract

Pharmaceutically relevant Suzuki-Miyaura cross-couplings (SMCs) often require designer phosphine ligands and palladium loadings above 1 mol% to couple Lewis basic, sterically congested substrates. Recent work has demonstrated that nickel is an attractive alternative to palladium for facile SMCs, but further ligand development is required for Ni catalysis to rival Pd for more challenging couplings. We applied prior work on monophosphine ligand design for Ni to develop a bisphosphine, DiploPhos, that outperforms state-of-the-art ligands for Ni to achieve sterically hindered Ni SMCs with ≥3

Indexed as

cross-couplingligand designNi catalysisorganometallic studiesphosphinesSuzuki–Miyaura

Identifiers

PMID42851917
PMCPMC13647468

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.