Evidence map›Paper›PMID 42851857›Full record

ArticleACS omega2026

Interactions between Tick-Borne Encephalitis Virus Nonstructural Protein 1 and Blood-Brain Barrier Tight Junction Proteins: Potential Clues to Strain-Specific Neuropathogenicity.

Jarinya Chaopreecha, Jordan Liburd, Shahid Khalid, Songeziwe Ntsimango, Ian M Jones, Jennifer H Tomlinson, Niluka Goonawardane

Abstract read
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jarinya ChaopreechaSchool of Molecular and Cellular Biology Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, U.K.
Jordan LiburdAstbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, U.K.
Shahid KhalidSchool of Molecular and Cellular Biology Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, U.K.
Songeziwe NtsimangoMolecular Sciences Institute, School of Chemistry, University of the Witwatersrand, PO Wits, Johannesburg 2050, South Africa.
Ian M JonesSchool of Biological Sciences, University of Reading, Reading RG6 6UR, U.K.
Jennifer H TomlinsonAstbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, U.K.
Niluka GoonawardaneAstbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, U.K.ORCID https://orcid.org/0000-0003-2906-5513

Funding

Wellcome Trust
6 · The paper itself

Abstract

Tick-borne encephalitis virus (TBEV) invades the central nervous system (CNS) through strain-specific mechanisms that remain poorly understood. For mosquito-borne orthoflaviviruses such as dengue and yellow fever viruses, the nonstructural protein 1 (NS1) has been shown to disrupt endothelial barrier integrity by targeting tight junction proteins (TJPs), facilitating viral neuroinvasion. However, comparable mechanisms in TBEVs remain largely unexplored. Here, we investigated the potential interaction of NS1 from high (Hypr)- and low (Vs)-pathogenic TBEV strains with different blood-brain barrier (BBB) TJPs, using AlphaFold3 (AF3) multimer modeling and

Identifiers

PMID42851857
PMCPMC13647419

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.