ReviewACS omega2026
ZIF-8-Based Smart-Responsive Nanocomposites for Cutaneous Wound Healing: A Review.
Review in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cutaneous wound healing is a complex process that requires precise management. In recent years, intelligent, responsive biomaterials have played a crucial role in guiding wound healing through these stages in a physiologically ordered manner. Zeolitic imidazolate framework-8 (ZIF-8), a subclass of metal-organic frameworks (MOFs), has received extensive attention in the biomedical field due to its intrinsic pH-responsive biodegradability, adjustable porosity and surface area, inherent antibacterial activity, and excellent biocompatibility. This Review provides a comprehensive and systematic overview of recent advances in ZIF-8-based smart-responsive nanocomposites for cutaneous wound repair. We first elaborate on the multifunctional roles of ZIF-8 across distinct phases of the wound healing cascade, including anti-infection, hemostasis, inflammation, proliferation, and remodeling. Subsequently, we critically discuss diverse delivery strategies employing ZIF-8 as a nanocarrier for therapeutic agents such as natural extracts, metals and their derivatives, biomacromolecules, functional drugs, and bioactive gases. A particular focus is placed on intelligent, responsive modifications of ZIF-8-based nanocomposites, which enable on-demand drug release and adaptive functionality in response to specific wound microenvironmental cues, including internal stimuli (temperature, pH, reactive oxygen species (ROS), glucose, and ATP) and external stimuli (light, magnetic fields, and ultrasound). Diverse application forms of ZIF-8 nanocomposites are extensively discussed, encompassing hydrogels, electrospun membranes, and microneedle patches. Finally, we present tailored design strategies of smart-responsive ZIF-8-based biomaterials for different wound scenarios, including diabetic wounds, infected wounds, burn injuries, and penetrating trauma. This Review aims to offer valuable insights and practical guidance for the rational design of next-generation intelligent wound care systems, while addressing current challenges and future perspectives in clinical translation.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.