Evidence map›Paper›PMID 42851843›Full record

ArticleFrontiers in medicine2026

Risk factors for HR-HPV persistence and residual or recurrent high-grade squamous intraepithelial neoplasia after LEEP.

Liya Wang, Yiran Zhang, Yi Chen, Ying Xu, Lei Bao, Dan Cao, Dan Wu

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Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Liya Wang *The Center for Cervical Disease, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Yiran Zhang *The Center for Cervical Disease, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Yi ChenThe Center for Cervical Disease, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Ying XuThe Center for Cervical Disease, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Lei BaoThe Center for Cervical Disease, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Dan CaoThe Center for Cervical Disease, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Dan WuThe Center for Cervical Disease, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: To investigate factors associated with persistent high-risk human papillomavirus (HR-HPV) infection and residual or recurrent disease in patients with high-grade squamous intraepithelial lesions (HSIL) following loop electrosurgical excision procedure (LEEP). Methods: A total of 903 patients with pathologically confirmed HSIL who underwent LEEP between January 2021 and May 2024 were retrospectively enrolled. HR-HPV genotyping and cervical cytology were performed before and after surgery, and residual or recurrent HSIL was assessed by colposcopy during follow-up. Generalized estimating equation (GEE) logistic regression accounted for within-patient clustering of genotype-specific HPV observations. Multivariable logistic regression identified factors associated with HR-HPV persistence, and Firth's penalized logistic regression evaluated factors associated with residual or recurrent HSIL. Results: Persistent HR-HPV infection rates were 23.3%, 19.0%, and 17.5% at 6, 12, and 18 months after LEEP, respectively. GEE analysis showed significant differences in type-specific persistence among the Conclusions:

Indexed as

cervical intraepithelial neoplasiahigh-grade squamous intraepithelial lesionshuman papillomavirus speciesloop electrosurgical excision procedurerisk factors

Identifiers

PMID42851843
PMCPMC13647321

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