ArticleFrontiers in pain research (Lausanne, Switzerland)2026
Targeted modulation of thalamocortical and descending control networks in chronic shoulder pain: a longitudinal connectomics study.
Article in Frontiers in pain research (Lausanne, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Central sensitization involves maladaptive plasticity in ascending nociceptive and descending modulatory pathways. This pilot study was designed with three integrated aims: (1) to characterize baseline thalamocortical and descending control network abnormalities in chronic shoulder pain (CSP) relative to healthy controls; (2) to examine whether these network features change following a standardized course of peripheral myofascial stimulation (PMS); and (3) to explore potential mechanistic pathways linking peripheral intervention to central network reconfiguration. While PMS has been reported anecdotally as effective for musculoskeletal pain, preliminary empirical evidence from randomized controlled trials remains limited, and its central neural mechanisms remain unclear. Methods: Twelve patients with CSP underwent longitudinal resting-state fMRI before and after a 10-session PMS intervention. A matched healthy control cohort ( Results: At baseline, patients exhibited trend-level reduced thalamo-somatosensory coupling (Cohen's d = 0.72, Conclusions: PMS is associated with the reconfiguration of specific bottom-up gating and top-down control circuits in CSP. While the absence of a sham control and the small sample size (
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.