ArticleFrontiers in neurology2026
Baseline CT radiomics for early prediction of post-traumatic hydrocephalus in traumatic brain injury: development and temporal validation.
Article in Frontiers in neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Post-traumatic hydrocephalus (PTH) impairs recovery after traumatic brain injury (TBI), yet reliable early risk stratification based solely on baseline assessment remains limited. We aimed to develop and temporally validate a preoperative CT-based radiomics model for early prediction of PTH and to assess the incremental value of clinical predictors. Methods: In this retrospective single-center cohort, 341 consecutive adults undergoing neurosurgical treatment for TBI were included. Patients treated in 2021-2023 ( Results: PTH occurred in 27.3% of the training cohort and 23.1% of the validation cohort. In temporal validation, the clinical, radiomics, and fusion models achieved AUCs of 0.769 (95% CI, 0.608-0.906), 0.783 (95% CI, 0.604-0.929), and 0.865 (95% CI, 0.735-0.958), respectively. The fusion model also demonstrated acceptable calibration and greater net benefit across clinically relevant thresholds. Conclusion: Baseline preoperative CT radiomics enables early risk stratification of PTH after TBI. Integration with clinical predictors provides incremental predictive value under temporal validation and may support individualized surveillance.
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