SynthesisFrontiers in cellular and infection microbiology2026
Biopsychosocial determinants of tuberculosis care and treatment outcomes: a scoping review and bibliometric analysis.
Synthesis in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Tuberculosis (TB) remains the leading infectious-disease cause of death globally, with an estimated 10.7 million incident cases and 1.23 million deaths in 2024. Its persistence is driven not by microbial factors alone, but by a complex interplay of biological, psychological, and social determinants influencing exposure, vulnerability, and access to care. Despite growing recognition of these biopsychosocial dimensions, the available evidence remains fragmented across disciplines, and no previous review has comprehensively mapped their scope while simultaneously characterizing the structure and evolution of this research field. Methods: We conducted an integrated scoping review and bibliometric analysis. Scopus, PubMed, and Web of Science were searched from database inception through 21 January 2026. Empirical studies examining biological, psychological, or social determinants associated with TB care or treatment outcomes were eligible. Data were extracted using a structured charting framework following Joanna Briggs Institute (JBI) methodology and reported according to the PRISMA Extension for Scoping Reviews (PRISMA-ScR). Bibliometric analyses were performed using VOSviewer and the Bibliometrix R package to characterize publication trends, collaboration networks, and thematic evolution. Study-specific effect estimates were summarized descriptively where available; meta-analysis was not undertaken because of substantial clinical and methodological heterogeneity. Results: A total of 124 studies were included, identifying 78 determinants across biological (n = 25), psychological (n = 25), and social (n = 28) domains. HIV co-infection, diabetes, malnutrition, smoking, alcohol use, stigma, limited TB knowledge, poverty, and barriers to healthcare access were consistently associated with delayed diagnosis, poor treatment adherence, multidrug-resistant TB (MDR-TB), unsuccessful treatment outcomes, and mortality. Bibliometric analysis demonstrated sustained growth in research output and an expansion from predominantly biomedical topics toward mental health, social determinants, digital health, and data-driven approaches. Integration of findings identified evidence gaps, with several determinants strongly associated with adverse outcomes receiving comparatively limited research attention. Conclusion: Integrating a scoping review with bibliometric analysis provides a comprehensive understanding of biopsychosocial determinants associated with TB care and treatment outcomes while identifying evidence gaps and emerging research priorities. These findings support multidisciplinary TB control strategies addressing biological, psychological, and social determinants to strengthen person-centered care. Systematic review registration: https://osf.io/8fpky/, identifier 8fpky.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.