ArticleFrontiers in oncology2026
Prognostic significance of co-expression of c-MET and EGFR in locally advanced and metastatic gastric cancer: a retrospective cohort study.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Gastric cancer (GC) remains a leading cause of cancer-related mortality globally. While molecular targeted therapies against HER2 and PD-L1 have advanced, the role of receptor tyrosine kinase (RTK) co-activation, specifically between c-MET and EGFR, remains elusive in GC. This study aimed to investigate the correlation between c-MET and EGFR overexpression and clinicopathological features and prognosis in patients with gastric cancer, and to reveal prognostic significance of co-expression of c-MET and EGFR in gastric adenocarcinoma. Methods: The clinicopathological data of 214 Chinese patients with GC were retrospectively analyzed, and the expression level of c-MET and EGFR were detected by immunohistochemistry. χ Results: The positive expression rates for c-MET and EGFR were 21.96% (47/214) and 68.22% (146/214), respectively. c-MET overexpression was significantly served as an independent predictor of poor OS ( Conclusion: c-MET overexpression is a robust prognostic indicator of adverse outcomes in GC. The frequent co-expression of c-MET and EGFR suggests a potential mechanism of RTK cross-talk, warranting further investigation into dual-targeted therapeutic strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.