ArticleFrontiers in aging neuroscience2026
Low-density lipoprotein cholesterol modulates amyloid-related entorhinal vulnerability and episodic memory performance in older adults.
Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Cerebral amyloid-beta (Aβ) burden does not fully explain variation in Alzheimer's disease (AD)-related brain structure and episodic memory. We examined whether circulating low-density lipoprotein cholesterol (LDL-C) modifies the cross-sectional statistical association between Aβ burden, the entorhinal cortex (EC) thickness and episodic memory performance. Methods: Cross-sectional data from 1,253 individuals in the Gwangju Alzheimer's Disease and Related Dementias cohort (798 cognitively normal, 425 mild cognitive impairment, 30 AD dementia) were analyzed. Primary conditional-process models were adjusted for age, sex, education, body mass index, and HbA1c; clinical diagnosis was examined in sensitivity analyses. HC3 heteroskedasticity-consistent inference was used for the focal interaction, and indirect associations were estimated using 10,000 bootstrap resamples. Results: Greater Aβ burden was associated with lower EC thickness (β = -0.0863, Conclusion: Circulating LDL-C was associated with modest heterogeneity in the cross-sectional Aβ-EC relationship, with more clearly negative conditional associations observed at higher LDL-C levels. Longitudinal studies are needed to determine the temporal and clinical relevance of these findings.
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