Evidence map›Paper›PMID 42851347›Full record

ArticleFrontiers in cellular and infection microbiology2026

The IL-17A/TNFSF10 axis promotes vulvovaginal candidiasis pathogenesis by inducing neutrophil necroptosis.

Mingkun Shao, Wanqin Hu, Hongxiao Feng, Sainan Li, Wenjin Qi, Yang Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mingkun ShaoDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Kunming Medical University, Yunnan, China.
Wanqin HuDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Kunming Medical University, Yunnan, China.
Hongxiao FengDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Kunming Medical University, Yunnan, China.
Sainan LiDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Kunming Medical University, Yunnan, China.
Wenjin QiDepartment of Obstetrics and Gynecology, The First Affiliated Hospital of Kunming Medical University, Yunnan, China.
Yang LiuDepartment of Obstetrics and Gynecology, The Second Affiliated Hospital of Kunming Medical University, Yunnan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Vulvovaginal candidiasis (VVC) is a common infection of the female reproductive tract and is closely associated with dysregulated mucosal immunity. This study investigated how IL-17A/TNFSF10 signaling regulates neutrophil death and VVC progression. Methods: Clinical specimens, RNA sequencing, cell-based assays, and mouse models were used. Results: IL-17A enhanced neutrophil extracellular trap formation and increased TNFSF10/TNFRSF10 expression, together with increased phosphorylation of RIP3 and MLKL. Discussion: These findings suggest that IL-17A/TNFSF10 signaling contributes to neutrophil death, mucosal inflammation, and VVC progression. Targeting this pathway may represent a potential therapeutic strategy for VVC.

Indexed as

Candidiasis, VulvovaginalInterleukin-17NecroptosisNeutrophilsAnimalsDisease Models, AnimalExtracellular TrapsFemaleHumansMiceMice, Inbred C57BLNeutrophil InfiltrationSignal TransductionInterleukin-17interleukin-17AnecroptosisneutrophilsTNFSF10vulvovaginal candidiasis

Identifiers

PMID42851347
PMCPMC13645517

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.