SynthesisFrontiers in nutrition2026
Enteral nutrition interruption in critically ill patients: a systematic review and meta-analysis of prevalence, causes, and clinical outcomes.
Synthesis in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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8 authors.
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Abstract
Introduction: Enteral nutrition interruption (ENI) is common in critically ill patients and may compromise nutritional delivery, but its prevalence, causes, and clinical consequences remain uncertain. This systematic review and meta-analysis synthesized evidence on ENI prevalence, contributing factors, clinical outcomes, and potential interventions. Methods: PubMed, Embase, CINAHL, Web of Science, Cochrane Library, CNKI, and WanFang Data were searched from inception through December 2025. Studies of critically ill adults receiving enteral nutrition were eligible. The review followed PRISMA guidance and was registered in PROSPERO (CRD420251266654). Random-effects models, subgroup analyses, sensitivity analyses, and GRADE assessments were performed. Results: Forty-one studies involving 8,260 critically ill patients were included. Crude ENI prevalence ranged from 11.2% to 100%, with a median of 68.5% (IQR, 57.1%-96.6%). The estimated pooled prevalence was 79.2%, although heterogeneity was extreme ( Discussion: ENI appears common and is predominantly procedure-related. It is associated with reduced energy adequacy, whereas its effects on ICU length of stay and short-term mortality remain uncertain because of inconsistent ENI definitions, substantial heterogeneity, publication bias, and limited outcome data. Standardized definitions, shorter peri-procedural fasting, improved gastrointestinal management, and multidisciplinary nutrition protocols may reduce avoidable interruptions. High-quality prospective studies and randomized trials are needed. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251266654.
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