Evidence map›Paper›PMID 42851262›Full record

ArticlebioRxiv : the preprint server for biology2026

Alternative splicing plasticity of the neurexin family of synaptic adhesion molecules in human sensory neurons.

Judy J Yoo, Bryan A Copits

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Judy J YooWashington University Pain Center, Department of Anesthesiology, Washington University School of Medicine; St. Louis, MO.
Bryan A CopitsWashington University Pain Center, Department of Anesthesiology, Washington University School of Medicine; St. Louis, MO.ORCID 0000-0003-3732-890X

Funding

Multi-omics peripheral nerve atlas enables fine-mapping of pain molecular phenotypesU19NS130607 · NINDS · WASHINGTON UNIVERSITY · PI Valeria Cavalli · 2022 to 2026
$14.0M
Synaptic mechanisms of somatosensory circuit assemblyR01NS130046 · NINDS · WASHINGTON UNIVERSITY · PI Bryan Copits · 2023 to 2026
$2.0M
NINDS NIH HHS R01 NS130046NINDS NIH HHS U19 NS130607
6 · The paper itself

Abstract

Plasticity within somatosensory circuits enables adaptations to environmental changes, however these can become maladaptive following injury and lead to chronic pain states. Presynaptic neurexins (Nrxns) are key organizers of synapse function that bind to a wide variety of postsynaptic proteins in a splice-isoform dependent manner to regulate synaptic connectivity, transmission and plasticity. Here we observed that

Identifiers

PMID42851262
PMCPMC13643856

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.