Evidence map›Paper›PMID 42851246›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Associations between plasma biomarker levels and quantitative postmortem neuropathologic measures in Alzheimer's disease and related dementias.

Celia R Bianco, Neus Rabaneda-Lombarte, Hadia Fatima, Johanna Celedon, Derek H Oakley, Steven E Arnold, Pia Kivisäkk, Alberto Serrano-Pozo

Abstract read
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In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Celia R BiancoNeurology Department, Mass General Brigham, Boston, Massachusetts, USA.ORCID https://orcid.org/0009-0009-1850-0023
Neus Rabaneda-LombarteNeurology Department, Mass General Brigham, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-0781-4256
Hadia FatimaNeurology Department, Mass General Brigham, Boston, Massachusetts, USA.
Johanna CeledonNeurology Department, Mass General Brigham, Boston, Massachusetts, USA.
Derek H OakleyHarvard Medical School, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-6998-9510
Steven E ArnoldNeurology Department, Mass General Brigham, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-9487-415X
Pia KivisäkkNeurology Department, Mass General Brigham, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0001-9708-7509
Alberto Serrano-PozoNeurology Department, Mass General Brigham, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0003-0899-7530

Funding

Research Education ComponentP30AG062421 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI STEVEN E ARNOLD · 2019 to 2026
$36.5M
The Role of Reactive Astrocytes in the Propagation and Clearance of Tau in Alzheimer's DiseaseR01AG089349 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Alberto Serrano-Pozo · 2025 to 2026
$975k
Reactive Astrogliosis and the Tripartite Synapse in Alzheimer's DiseaseR21AG087072 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI SERRANO-POZO, ALBERTO · 2025 to 2025
$453k
Alzheimer's Association AARG-24-1309896Alzheimer's Association ABA-25-1373553Fundación Ramón Areces Research Fellowship BEVP36A7461NIA NIH HHS P30 AG062421NIA NIH HHS R01 AG089349NIA NIH HHS R01AG089349NIA NIH HHS R21 AG087072NIA NIH HHS R21AG087072
6 · The paper itself

Abstract

introductionValidation of Alzheimer's disease blood-based biomarkers (BBMs) has relied largely on amyloid beta (Aβ) and tau positron emission tomography (PET), with limited quantitative neuropathologic correlation studies. We examined associations between BBMs and quantitative postmortem neuropathology in 124 participants from the Massachusetts Alzheimer's Disease Research Center (MADRC) Longitudinal Cohort Study.

methodsPlasma phosphorylated tau 217 (p-tau217), p-tau181, total tau (t-tau), neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP) were measured using the Meso Scale Discovery platform and correlated with postmortem quantitative measures of Aβ plaques, AT8

resultsPlasma p-tau217 strongly associated with Aβ plaques (especially neuritic) and AT8 DISCUSSION: These findings support BBM biological specificity and utility for in vivo characterization of distinct neuropathologic processes.

Indexed as

Alzheimer DiseaseBiomarkersBrainDementiatau ProteinsAgedAged, 80 and overAmyloid beta-PeptidesAstrocytesAutopsyFemaleGlial Fibrillary Acidic ProteinHumansLongitudinal StudiesMaleNeurofilament ProteinsAmyloid beta-PeptidesBiomarkersGFAP protein, humanGlial Fibrillary Acidic Proteinneurofilament protein LNeurofilament Proteinstau ProteinsAlzheimeramyloid beta plaquesblood biomarkerneurofibrillary tanglestau

Identifiers

PMID42851246
PMCPMC13650605

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.