Evidence map›Paper›PMID 42851166›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Longitudinal associations of rapid eye movement (REM) sleep and slow-wave sleep with plasma Alzheimer's disease biomarkers.

Jeongyeon Hwang, Luisa F Figueredo, Daphne I Valencia, Thomas M Tolbert, Eriko Hamada, Li Zhou, Joshua L Gills, Joaquin Ruiz, Katarina R Martillo, Sarah S Chu and 10 more

Abstract read
PubMed Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Jeongyeon HwangThe Barbara and Maurice Deane Center for Wellness and Cognitive Health, Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Luisa F FigueredoHealthy Brain Aging and Sleep Center, Department of Psychiatry, NYU Grossman School of Medicine, New York, New York, USA.
Daphne I ValenciaDavid M. Rapoport Sleep Research Laboratory, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Thomas M TolbertDavid M. Rapoport Sleep Research Laboratory, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Eriko HamadaDavid M. Rapoport Sleep Research Laboratory, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Li ZhouDavid M. Rapoport Sleep Research Laboratory, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Joshua L GillsHealthy Brain Aging and Sleep Center, Department of Psychiatry, NYU Grossman School of Medicine, New York, New York, USA.
Joaquin RuizHealthy Brain Aging and Sleep Center, Department of Psychiatry, NYU Grossman School of Medicine, New York, New York, USA.
Katarina R MartilloDavid M. Rapoport Sleep Research Laboratory, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Sarah S ChuDavid M. Rapoport Sleep Research Laboratory, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Ankita KumarDavid M. Rapoport Sleep Research Laboratory, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Esther M BlessingHealthy Brain Aging and Sleep Center, Department of Psychiatry, NYU Grossman School of Medicine, New York, New York, USA.
Omonigho M BubuHealthy Brain Aging and Sleep Center, Department of Psychiatry, NYU Grossman School of Medicine, New York, New York, USA.
Ankit ParekhDavid M. Rapoport Sleep Research Laboratory, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Korey KamDavid M. Rapoport Sleep Research Laboratory, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Anna E MullinsDavid M. Rapoport Sleep Research Laboratory, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
David M RapoportDavid M. Rapoport Sleep Research Laboratory, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Indu AyappaDavid M. Rapoport Sleep Research Laboratory, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Ricardo S OsorioHealthy Brain Aging and Sleep Center, Department of Psychiatry, NYU Grossman School of Medicine, New York, New York, USA.
Andrew W VargaDavid M. Rapoport Sleep Research Laboratory, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID https://orcid.org/0000-0002-3668-3371

Funding

Research Education ComponentP30AG066514 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Margaret Sewell · 2020 to 2026
$31.0M
Effects of Successful OSA TreatmENT on Memory and AD BIomarkers in Older AduLts (ESSENTIAL)R01AG080609 · NIA · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI OSORIO, RICARDO S, STONE, KATIE L · 2023 to 2024
$7.4M
Slow wave sleep (SWS) and the effect of African ancestry on amyloid burden, a longitudinal studyR01AG056531 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JEAN-LOUIS, GIRARDIN, OSORIO, RICARDO S · 2018 to 2022
$6.7M
Sleep Aging and Risk for Alzheimer's disease-Resubmission-1R01AG056031 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI OSORIO, RICARDO S · 2018 to 2022
$4.4M
Impact of sleep apnea and its treatment on memory and tau accumulation in the brainR01AG066870 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI OSORIO, RICARDO S, VARGA, ANDREW W · 2020 to 2024
$3.7M
Multidisciplinary Research Training in Sleep ScienceT32HL160511 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI INDU A AYAPPA, ANDREW W VARGA · 2023 to 2026
$1.5M
Alzheimer's AssociationAlzheimer's Association AARFD-24-1306796American Thoracic Society ASPIRE FellowshipAmerican Thoracic Society (ATS)NHLBI NIH HHS T32 HL160511NIA NIH HHS P30 AG066514NIA NIH HHS R01 AG056031NIA NIH HHS R01 AG066870NIA NIH HHS R01 AG080609NIH R01AG056531
6 · The paper itself

Abstract

introductionData on how sleep architecture relates to progression of plasma Alzheimer's disease biomarkers remains limited.

methodsSixty-four cognitively unimpaired older adults (ages 55-90) underwent plasma collection twice 2.6 years apart and polysomnography proximate to the first plasma collection. Plasma amyloid beta (Aβ) 42 and 40 were measured via mass spectrometry.

resultsFrontal slow-wave activity (SWA) was inversely associated with plasma Aβ42/40 at cross-section in bivariate analysis and in a covariate-adjusted model. In comparison, low rapid eye movement (REM) sleep percentage was associated with a large longitudinal decline in annualized blood-based Aβ42/40. In exploratory analyses, the association between low REM sleep percentage and faster decline in Aβ42/40 ratio was stronger in the amyloid-positive group. DISCUSSION: In cognitively unimpaired older adults, non-REM SWA correlates with cross-sectional amyloid load, whereas REM sleep may predict accelerated amyloid accumulation in preclinical stage, suggesting both may serve as early biomarkers and modifiable interventional targets.

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesPeptide FragmentsSleep, REMSleep, Slow-WaveAgedAged, 80 and overBiomarkersCross-Sectional StudiesDisease ProgressionFemaleHumansLongitudinal StudiesMaleMiddle AgedPolysomnographyAmyloid beta-Peptidesamyloid beta-protein (1-40)amyloid beta-protein (1-42)BiomarkersPeptide Fragmentsamyloidcognitively unimpaired older adultsplasma biomarkersrapid eye movement sleepslow‐wave activity

Identifiers

PMID42851166

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.