Trial reportAnnals of medicine2026
Lung ultrasound-guided protocolized fluid management versus conventional central venous pressure-based management in monitoring extravascular lung water during the perioperative period of percutaneous nephrolithotomy: a randomized controlled trial.
Trial report in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPercutaneous nephrolithotomy (PCNL) is a common surgical intervention to treat renal calculi. Excessive irrigation fluid absorption during surgery may enhance extravascular lung water (EVLW) level. Hence, accurate monitoring and protocolized management of EVLW are crucial for preventing postoperative complications.
methodsOur randomized controlled study enrolled 181 cases undergoing elective PCNL and randomly divided them to conventional CVP-based fluid management (Group C) or lung ultrasound-guided protocolized fluid management (Group LUS). Primary outcomes included increased incidence of EVLW and severity within 30 min postoperatively and postoperative hypoxemia in the two groups. Secondary outcomes were the CVP values and LUS scores at the following time points: before irrigation (T0), at the first administration of furosemide (T1), after irrigation (T2), and at the time of leaving the post-anesthesia care unit (PACU) (T3). Moreover, included fluid volumes (crystalloid, colloid, total infusion, irrigation, and supplemental fluid at first furosemide administration), total furosemide dosage. The anesthesia time, surgical duration, PACU stay time, extubation time, and total hospital stay were recorded. Safety outcomes included perioperative complication rates.
resultsCompared with Group C, Group LUS demonstrated significantly lower incidence and severity of EVLW increase within 30 min postoperatively, as well as reduced postoperative hypoxemia rate (all
conclusionsAn LUS-guided fluid management protocol integrating real-time EVLW assessment with predefined intervention thresholds outperformed conventional CVP-based management during the perioperative period of PCNL. The superior sensitivity of LUS for detecting early EVLW elevation, combined with protocolized early intervention, reduced postoperative hypoxemia incidence, shortened extubation time and PACU stay duration, and improved short-term perioperative recovery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.