Evidence map›Paper›PMID 42851117›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Association between early-life farming exposure and Alzheimer's disease neuropathological burden.

W Ryan Powell, Eleanna M Melcher, Rachel C Otte, Sarah Lim, Lauren Etter, Aly Pfaff, Amanda DeWitt, Adrienne R S Lee, Fred B Ketchum, M Shahriar Salamat and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

W Ryan PowellCenter for Health Disparities Research, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Eleanna M MelcherCenter for Health Disparities Research, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Rachel C OtteCenter for Health Disparities Research, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Sarah LimCenter for Health Disparities Research, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Lauren EtterDepartment of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Aly PfaffCenter for Health Disparities Research, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Amanda DeWittCenter for Health Disparities Research, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Adrienne R S LeeCenter for Health Disparities Research, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Fred B KetchumCenter for Health Disparities Research, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
M Shahriar SalamatDepartment of Neurological Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Christopher A BradfieldMolecular & Environmental Toxicology Center, University of Wisconsin, Madison, Wisconsin, USA.
Stephen A GoutmanDepartment of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
Megan L ZuelsdorffUniversity of Wisconsin School of Nursing, Madison, Wisconsin, USA.
Kelly M BakulskiUniversity of Michigan School of Public Health, Ann Arbor, Michigan, USA.
Robert A RissmanDepartment of Physiology and Neuroscience, Alzheimer's Therapeutic Research Institute, Keck School of Medicine of the University of Southern California, San Diego, California, USA.

Funding

The Neighborhoods Study: Contextual Disadvantage and Alzheimer’s Disease and Related Dementias (ADRD)R01AG070883 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI AMY J. KIND · 2021 to 2026
$42.1M
Wisconsin Alzheimer's Disease Research CenterP30AG062715 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Barbara Brigitta Bendlin · 2019 to 2026
$34.5M
USCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI, ARTHUR W TOGA · 2020 to 2026
$27.8M
Impact of TBI and Cognitive Decline on Alzheimer's Disease Brain-Derived Exosome CargoR01AG079303 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Victoria B Risbrough, Robert Rissman · 2026 to 2026
$645k
Feasibility of Linking the Occupational Exposome to Alzheimer's Disease NeuropathologyR21AG079277 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI POWELL, WILLIAM RYAN · 2022 to 2023
$414k
National Institute on Aging Awards P30AG062715National Institute on Aging Awards P30AG066530National Institute on Aging Awards R01AG070883National Institute on Aging Awards R01AG079303National Institute on Aging Awards R21AG079277NIA NIH HHS P30 AG062715NIA NIH HHS P30 AG066530NIA NIH HHS R01 AG070883NIA NIH HHS R01 AG079303NIA NIH HHS R21 AG079277
6 · The paper itself

Abstract

backgroundFarming populations may face a disproportionate share of adverse exposures influencing Alzheimer's disease (AD), yet farming data are rarely connected to cohorts with characterized AD neuropathology. Whether early-life exposure is related to AD neuropathology is limited.

methodBrain donors from two Alzheimer's Disease Research Centers (N = 1035; between 1986-2018) were included. US Census records were used to identify those with early-life farming exposure (birth to 17 years old) and examined alongside AD neuropathology assessments.

resultEarly-life farming exposure (≈ 17% of donors) was associated with 60% higher odds of AD neuropathological burden (odds ratio = 1.60, 95% confidence interval: 1.09-2.35) adjusting for age, sex, and year of death.

conclusionFindings suggest exposure to farming early in life is linked to increased levels of AD neuropathology. Deeper occupational and residential phenotyping is needed to identify the potential multiple, overlapping risk pathways, which may include cumulative and sensitive life stage exposure to chemical toxicants, hearing loss, and psychosocial hazards.

Indexed as

AgricultureAlzheimer DiseaseBrainEnvironmental ExposureAdolescentAgedAged, 80 and overChildChild, PreschoolFemaleHumansInfantInfant, NewbornMaleMiddle AgedNeuropathologyAlzheimer's disease riskamyloid positivityfarmingneurofibrillary pathologyneuropathologyoccupational exposomeoccupational risk factorssocial exposome

Identifiers

PMID42851117
PMCPMC13650515

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.