ArticleChemMedChem2026
Synthesis, Antiparasitic Activity, and ADME Profile of Morpholinephenylbenzamides: A Pharmacological Study Against Chagas Disease and Visceral Leishmaniasis.
Danilo Nascimento Farago, Daniela de Melo Resende, Mariza Gabriela Faleiro de Moura Lodi Cruz, Rafaela Marçal Sousa, Rafael Consolin Chelucci, Simone Michelan-Duarte, Felipe da Silva Mendonça de Melo, Douglas Davison da Silva Oliveira, Paula Derksen Macruz, Alexandra Maria Dos Santos Carvalho and 6 more
Abstract read
In one paragraphArticle in ChemMedChem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
16 authors.
Daniela de Melo ResendeGrupo Genômica Funcional de Parasitos, Instituto René Rachou, Fundação Oswaldo Cruz (FIOCRUZ Minas), Belo Horizonte, Minas Gerais, Brazil.
Mariza Gabriela Faleiro de Moura Lodi CruzGrupo Genômica Funcional de Parasitos, Instituto René Rachou, Fundação Oswaldo Cruz (FIOCRUZ Minas), Belo Horizonte, Minas Gerais, Brazil.ORCID https://orcid.org/0000-0003-0828-790X Rafaela Marçal SousaLaboratório de Síntese de Candidatos a Fármacos, Instituto de Química, Universidade Federal de Uberlândia (UFU), Uberlândia, Minas Gerais, Brazil.
Rafael Consolin ChelucciLaboratório de Química Medicinal e Computacional (LQMC), Instituto de Física de São Carlos (IFSC), Universidade de São Paulo (USP), São Carlos, São Paulo, Brazil.ORCID https://orcid.org/0009-0008-4099-9986 Simone Michelan-DuarteLaboratório de Química Medicinal e Computacional (LQMC), Instituto de Física de São Carlos (IFSC), Universidade de São Paulo (USP), São Carlos, São Paulo, Brazil.
Felipe da Silva Mendonça de MeloPathogen-Host Interface Laboratory, Department of Cell Biology, University of Brasilia (UnB), Brasília, Distrito Federal, Brazil.
Douglas Davison da Silva OliveiraLaboratório de Síntese de Candidatos a Fármacos, Instituto de Química, Universidade Federal de Uberlândia (UFU), Uberlândia, Minas Gerais, Brazil.ORCID https://orcid.org/0009-0002-9948-545X Paula Derksen MacruzLaboratório de Biomoléculas e Espectrometria de Massas (LaBioMass), Universidade Estadual de Maringá (UEM), Maringá, Paraná, Brazil.
Adriano D AndricopuloLaboratório de Química Medicinal e Computacional (LQMC), Instituto de Física de São Carlos (IFSC), Universidade de São Paulo (USP), São Carlos, São Paulo, Brazil.
Leonardo L G FerreiraLaboratório de Química Medicinal e Computacional (LQMC), Instituto de Física de São Carlos (IFSC), Universidade de São Paulo (USP), São Carlos, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-6947-0639 Silvane Maria Fonseca MurtaGrupo Genômica Funcional de Parasitos, Instituto René Rachou, Fundação Oswaldo Cruz (FIOCRUZ Minas), Belo Horizonte, Minas Gerais, Brazil.
Celso de Oliveira Rezende JúniorLaboratório de Síntese de Candidatos a Fármacos, Instituto de Química, Universidade Federal de Uberlândia (UFU), Uberlândia, Minas Gerais, Brazil.ORCID https://orcid.org/0000-0003-1402-2035 Funding
Conselho Nacional de Desenvolvimento Científico e Tecnológico 300079/2025-7,Conselho Nacional de Desenvolvimento Científico e Tecnológico 309994-2023-3Conselho Nacional de Desenvolvimento Científico e Tecnológico 316892/2023-8Conselho Nacional de Desenvolvimento Científico e Tecnológico 408678/2024-0Fundação de Amparo à Pesquisa do Estado de Minas Gerais APD-01401-25Fundação de Amparo à Pesquisa do Estado de Minas Gerais RED-00110-23Fundação de Amparo à Pesquisa do Estado de São Paulo 13/07600-3Fundação de Apoio à Pesquisa do Distrito Federal 00193-00002136/2023-01
6 · The paper itselfAbstract
Chagas disease and leishmaniasis are neglected tropical diseases with limited treatment options. This study reports a hit-to-lead optimization of morpholinephenylbenzamides, starting from hit 1, which showed potent activity against Trypanosoma cruzi (IC
Indexed as
Antiprotozoal AgentsBenzamidesChagas DiseaseLeishmania infantumLeishmaniasis, VisceralMorpholinesTrypanosoma cruziAnimalsDose-Response Relationship, DrugHumansMolecular StructureParasitic Sensitivity TestsStructure-Activity RelationshipAntiprotozoal AgentsBenzamidesMorpholinesdrug discoveryhit‐to‐leadneglected tropical diseases
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