Evidence map›Paper›PMID 42850933›Full record

Trial reportBrain and behavior2026

Exploring Associations Between Hypoxia, Serum Erythropoietin, and Cognition in Patients With Mood Disorders and Healthy Individuals.

Barbara Emilie Rotbøl Ørum, Johanna Mariegaard Schandorff, Viktoria Damgaard, Eya-Mist Rødgaard, Caroline Fussing Bruun, Morten Meyer, Lars Vedel Kessing, Martin Balslev Jørgensen, Kamilla Woznica Miskowiak

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Brain and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06121206 (Altitude-like Cognition Training to Target Brain Erythropoietin as a Novel Mechanism of Long-lasting Neuroplasticity and Cognitive Functions), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06121206 nacompletednot on this map

Altitude-like Cognition Training to Target Brain Erythropoietin as a Novel Mechanism of Long-lasting Neuroplasticity and Cognitive Functions

TypeinterventionalSponsorMental Health Centre Copenhagen, Bispebjerg and Frederiksberg HospitalRan2023 to 2025Enrolled190ConditionsCognitive Impairment, Bipolar Disorder, DepressionArmsAltitude-like hypoxia (12% O2), Normoxia (20% O2), Cognitive training, Sham training
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Barbara Emilie Rotbøl ØrumNeurocognition and Emotion Across Disorders of the Brain (NEAD) Centre, Psychiatric Centre Copenhagen, Frederiksberg Hospital, Frederiksberg, Denmark.ORCID https://orcid.org/0009-0009-3761-0420
Johanna Mariegaard SchandorffNeurocognition and Emotion Across Disorders of the Brain (NEAD) Centre, Psychiatric Centre Copenhagen, Frederiksberg Hospital, Frederiksberg, Denmark.ORCID https://orcid.org/0000-0001-6632-5025
Viktoria DamgaardNeurocognition and Emotion Across Disorders of the Brain (NEAD) Centre, Psychiatric Centre Copenhagen, Frederiksberg Hospital, Frederiksberg, Denmark.ORCID https://orcid.org/0000-0002-4257-3136
Eya-Mist RødgaardNeurocognition and Emotion Across Disorders of the Brain (NEAD) Centre, Psychiatric Centre Copenhagen, Frederiksberg Hospital, Frederiksberg, Denmark.ORCID https://orcid.org/0000-0002-3736-2238
Caroline Fussing BruunDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.ORCID https://orcid.org/0000-0001-9401-358X
Morten MeyerDepartment of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.ORCID https://orcid.org/0000-0002-9571-1336
Lars Vedel KessingDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.ORCID https://orcid.org/0000-0001-9377-9436
Martin Balslev JørgensenDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.ORCID https://orcid.org/0000-0002-1321-8901
Kamilla Woznica MiskowiakNeurocognition and Emotion Across Disorders of the Brain (NEAD) Centre, Psychiatric Centre Copenhagen, Frederiksberg Hospital, Frederiksberg, Denmark.ORCID https://orcid.org/0000-0003-2572-1384

Funding

European Research Council 101043416Lundbeck Foundation R432-2023-94
6 · The paper itself

Abstract

purposeModerate repeated hypoxia (MRH) has shown neuroprotective and neuroplastic effects, partly mediated by erythropoietin (EPO) via hypoxia-inducible factors (HIFs). This study examined the effects of 3 weeks of daily 3.5-h normobaric hypoxia (12% O

methodData from 84 healthy participants (HP) and 24 participants with remitted mood disorders (MD) in the ongoing ALTIBRAIN trial (NCT06121206) were analyzed. HP were randomized to MRH or normoxia (with/without cognitive training), while MD participants were randomized to MRH with cognitive training or treatment as usual. FINDING: MRH reduced SpO

conclusionMRH was safe and well-tolerated, influencing SpO

Indexed as

CognitionErythropoietinHypoxiaMood DisordersAdultBrain-Derived Neurotrophic FactorCognitive EnhancementCognitive TrainingFemaleHumansMaleMiddle AgedYoung AdultBrain-Derived Neurotrophic FactorErythropoietin

Identifiers

PMID42850933

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.