Evidence map›Paper›PMID 42850801›Full record

Trial reportPhotodermatology, photoimmunology & photomedicine2026

Daylight Photodynamic Therapy Alone or Combined With Transepidermal Drug Delivery Techniques for Skin Field Cancerization: An Immunohistochemical Study of Epidermal Carcinogenesis and Dermal Remodeling Markers.

Camila de Oliveira Bento, Luciana Pantaleão, Porphirio José Soares Filho, Ronir Raggio Luiz, Ronaldo Altenburg Odebrecht Curi Gismondi, Maria Claudia Almeida Issa

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Photodermatology, photoimmunology & photomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03963765 (Transepidermal Application of Metilaminolevulinate in Daylight Photodynamic Therapy in the Treatment of Photodamaged Skin), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03963765 nacompletednot on this map

Transepidermal Application of Metilaminolevulinate in Daylight Photodynamic Therapy in the Treatment of Photodamaged Skin

TypeinterventionalSponsorUniversidade Federal FluminenseRan2017 to 2020Enrolled40ConditionsSkin DiseasesArmsGroup I (Standard DL-PDT), Group II (DL-PDT with microneedles), Group III (DL-PDT with CO2 laser), Group IV (DL-PDT with microdermabrasion)
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Camila de Oliveira BentoDepartment of Clinical Medicine-Dermatology, Fluminense Federal University, Niterói, Brazil.ORCID https://orcid.org/0000-0002-4607-1432
Luciana PantaleãoDepartment of Pathology, Fluminense Federal University, Niterói, Brazil.ORCID https://orcid.org/0000-0001-7480-2530
Porphirio José Soares FilhoDepartment of Pathology, Fluminense Federal University, Niterói, Brazil.
Ronir Raggio LuizDepartment of Statistics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0002-7784-9905
Ronaldo Altenburg Odebrecht Curi GismondiDepartment of Clinical Medicine, Fluminense Federal University, Niterói, Brazil.ORCID https://orcid.org/0000-0002-0884-4190
Maria Claudia Almeida IssaDepartment of Clinical Medicine-Dermatology, Fluminense Federal University, Niterói, Brazil.ORCID https://orcid.org/0000-0003-1031-7370

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001Galderma
6 · The paper itself

Abstract

backgroundDaylight photodynamic therapy (DL-PDT) has been combined with transepidermal drug delivery (TED) techniques to enhance photosensitizer penetration. Although studies have suggested improved clinical and histological outcomes with DL-PDT combined with ablative laser, evidence regarding carcinogenesis and dermal remodeling markers remains limited.

objectiveTo evaluate changes in epidermal carcinogenesis and dermal remodeling markers after standard DL-PDT compared with DL-PDT combined with TED techniques for facial field cancerization.

methodsForty patients were randomized into four groups (n = 10): standard DL-PDT, DL-PDT with microneedling, DL-PDT with CO

resultsA reduction in the vertical extent of Ki67 expression (from two-thirds to one-third of the epidermis) was observed mainly in the microneedling and CO

conclusionsA trend toward reduced vertical Ki67 expression suggests potential benefit of DL-PDT combined with microneedling and CO

trial registrationClinicalTrials.gov: NCT03963765.

Indexed as

Aminolevulinic AcidDrug Delivery SystemsEpidermisPhotochemotherapyPhotosensitizing AgentsSkin NeoplasmsSunlightAgedFemaleHumansImmunohistochemistryKi-67 AntigenLasers, GasMaleMicroneedle Drug DeliveryMiddle AgedAminolevulinic AcidKi-67 Antigenmethyl 5-aminolevulinatePhotosensitizing Agentsdaylight photodynamic therapydermal remodelingKi67p53skin field cancerizationtransepidermal drug delivery

Identifiers

PMID42850801

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.