Evidence map›Paper›PMID 42850715›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Nuciferine Suppresses Inflammatory Hepatocarcinogenesis by Targeting cPLA2-Dependent Arachidonic Acid Metabolism.

Jing Sun, Xinyan Wu, Shuwei Luo, Yilang Liu, Jie Liu, Jun Lu, Weimin Wang, Xiao Feng, Tuo Zhang, Dipak Panigrahy and 3 more

Abstract read
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In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jing SunCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
Xinyan WuCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.ORCID https://orcid.org/0000-0002-2836-0804
Shuwei LuoCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
Yilang LiuCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.ORCID https://orcid.org/0009-0009-6600-4673
Jie LiuDepartment of General Surgery, Dazhou Central Hospital, Dazhou, China.
Jun LuDepartment of General Surgery, Peking University Third Hospital, Beijing, China.
Weimin WangCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
Xiao FengCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
Tuo ZhangCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.ORCID https://orcid.org/0000-0002-0900-9285
Dipak PanigrahyCenter For Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Jianjun DengState Key Laboratory of Vegetable Biobreeding, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing, China.ORCID https://orcid.org/0000-0002-3057-6997
Xiaojun LiaoCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.
Haixia YangCollege of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China.ORCID https://orcid.org/0000-0002-4410-9257

Funding

2115 Talent Development Program of China Agricultural UniversityNational Natural Science Foundation of China 32422069
6 · The paper itself

Abstract

Chronic inflammation is a hallmark of hepatocellular carcinoma (HCC) and is closely linked to aberrant arachidonic acid (AA) metabolism; however, whether AA mobilization is driven by defined upstream regulatory mechanisms and can be therapeutically targeted remains largely unresolved. Here, we identify cytosolic phospholipase A2 (cPLA2) as a central regulator of AA-dependent inflammatory signaling in hepatocarcinogenesis and a direct pharmacological target of nuciferine (NF). Using diethylnitrosamine (DEN)/carbon tetrachloride (CCl

Indexed as

arachidonic acid metabolismcytosolic phospholipase A2hepatocellular carcinomanuciferine

Identifiers

PMID42850715

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.