Increasing pH leads to more efficient production of polyhydroxyalkanoates from volatile fatty acids using Cupriavidus necator H16.

Steven Leonhardt, Birk Achenbach, Pravesh Tamang, Günter E M Tovar, Susanne Zibek

Abstract read

In one paragraph

Article in Microbial cell factories, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Steven LeonhardtFraunhofer Institute for Interfacial Engineering and Biotechnology IGB, Nobelstr. 12, 70569, Stuttgart, Germany.

Birk AchenbachInstitute of Interfacial Process Engineering and Plasma Technology IGVP, University of Stuttgart, Pfaffenwaldring 31, 70569, Stuttgart, Germany.

Pravesh TamangFraunhofer Institute for Interfacial Engineering and Biotechnology IGB, Nobelstr. 12, 70569, Stuttgart, Germany.

Günter E M TovarInstitute of Bioprocess Engineering and Pharmaceutical Technology IBPT, TH Mittelhessen University of Applied Sciences, Stuttgart, Germany.

Susanne ZibekFraunhofer Institute for Interfacial Engineering and Biotechnology IGB, Nobelstr. 12, 70569, Stuttgart, Germany. susanne.zibek@igvp.uni-stuttgart.de.

Funding

Ministry of the Environment, Climate Protection and the Energy Sector; The European Union Bioök_2076393

6 · The paper itself

Abstract

Volatile fatty acids (VFAs) are increasingly recognized as valuable feedstocks for the sustainable production of industrial chemicals in the context of a sustainable bioeconomy. However, their weak acidic character contributes to microbial toxicity. At lower pH values, VFAs predominantly occur in their undissociated form, which can permeate the cell membrane, disturb intracellular metabolism and increase the cellular energy burden. In this study, we investigated the effect of pH on microbial growth and polyhydroxyalkanoate (PHA) production in Cupriavidus necator H16 cultivated on a VFA mixture.To determine the influence of VFA concentrations on growth behaviour, batch experiments were conducted in microbioreactors using different concentrations of a VFA mixture. These experiments revealed multiphasic growth at VFA concentrations > 2.0 g∙L

Indexed as

Cupriavidus necatorFatty Acids, VolatilePolyhydroxyalkanoatesBatch Cell Culture TechniquesBioreactorsFermentationHydrogen-Ion ConcentrationFatty Acids, VolatilePolyhydroxyalkanoatesCupriavidus necatorFed-batchpHPHAVFAVolatile fatty acidsWeak acid toxicity

Identifiers

PMID42850640

DOI10.1007/s11814-013-0190-9

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.