ArticleJournal of cardiovascular translational research2026
Higher Myocardial miR-1-3p, miR-30a-5p, miR-34a-5p, and Lower miR208a-3p Levels are Associated with Lower Age at the Time of Heart Transplantation.
Article in Journal of cardiovascular translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Authors and funding
9 authors.
Funding
Abstract
Expression of microRNAs (miR-1-3p, miR-21-3p, miR-30a-5p, miR-34a-5p, miR-133a-3p, miR-208a-3p, and miR-423-5p) and mitochondrial unfolded protein response (UPRmt) genes (HSPA9, HSPD1, LONP1, OMA1, and YME1L) was investigated by qRT-PCR in six controls and 65 failing human hearts (33 ischemic cardiomyopathy (ICM), 28 dilated cardiomyopathy (DCM), 2 hypertrophic cardiomyopathy, and 1 non-compaction and restrictive cardiomyopathy each). Failing hearts had higher expression of miR-208a-3p, HSPA9, HSPD1, OMA1, YME1L and lower miR-1-3p expression compared to controls. Patients with higher miR-1-3p, miR-30a-5p, miR-34a-5p, (miR-423-5p exhibited a trend) and lower miR-208a-3p expression underwent heart transplantation or LVAD implantation earlier in life. DCM group had higher expression of miR-1-3p, miR-30a-5p, HSPD1, and LONP1 compared to the ICM group. Thus, myocardial expression of miR-1-3p, miR-30a-5p, miR-34a-5p, and miR-208a-3p could be associated with the HF progression; miR-208a-3p, HSPA9, HSPD1, OMA1, YME1L, and miR-1-3p could discriminate HF form control; and miR-1-3p, miR-30a-5p, HSPD1, and LONP1 could discriminate DCM from ICM.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.