Evidence map›Paper›PMID 42850450›Full record

ArticleNature aging2026

Heterogeneity in secondary follicle development buffers the lifespan of activated oocytes to optimize female fertility in mice.

Jing Liang, Xuebing Yang, Qian Li, Lingyu Li, Ge Wang, Lu Mu, Nan Sun, Kaiying Geng, Xindi Hu, Shudong Niu and 7 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jing Liang *State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Xuebing Yang *State Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Qian LiChinese Institute for Brain Research (CIBR), Beijing, China.
Lingyu LiState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Ge WangState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Lu MuState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Nan SunState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Kaiying GengState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Xindi HuState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Shudong NiuState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Longzhong JiaState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Yibo WangState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Xueqiang XuState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Zhen LiState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Fengchao WangTransgenic Animal Center, National Institute of Biological Sciences, Beijing, China.ORCID http://orcid.org/0000-0002-3595-2859
Yan ZhangState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China.
Hua ZhangState Key Laboratory of Animal Biotech Breeding, College of Biological Sciences, China Agricultural University, Beijing, China. huazhang@cau.edu.cn.ORCID http://orcid.org/0000-0002-4700-5971

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32541050National Natural Science Foundation of China (National Science Foundation of China) 82230051National Natural Science Foundation of China (National Science Foundation of China) 82371664Natural Science Foundation of Beijing Municipality (Beijing Natural Science Foundation) 5622014Natural Science Foundation of Beijing Municipality (Beijing Natural Science Foundation) L2609048
6 · The paper itself

Abstract

Oocyte activation and follicular development are fundamental for fertility in mammals, yet the dynamics of activated oocytes (Act-Oos) remain unclear. Here we use a Zp3-based lineage-tracing mouse model to label Act-Oos and reconstruct their developmental trajectories and folliculogenesis across the lifespan. We uncovered age-dependent heterogeneity in Act-Oo longevity: some oocytes activated in early adulthood progressed rapidly, whereas others persisted into late or even terminal reproductive stages, supporting long-term fertility. Further analyses revealed that Act-Oo lifespan is governed by secondary follicle (SF) progression, identifying SF development as a buffering mechanism that modulates female reproductive capacity. Mechanistically, transcriptional and metabolic states vary across Act-Oos, and differential FURIN expression modulates the release of oocyte-secreted factors, coordinating Act-Oo development with that of associated SFs and thereby regulating Act-Oo lifespan. Together, these findings provide a comprehensive in vivo developmental map of Act-Oo and mouse folliculogenesis, revealing dynamic control of female reproductive capacity.

Identifiers

PMID42850450

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.