Carmn sustains basal stemness in exocrine glands and CTND1-mediated Wnt signaling in mammary tissue.

Teng Wang, Mingyang Li, Yimin Fu, Minghao Liu, Yunkuan Jiang, Zhiwei Jiang, Yuyan Jiang, Zhuo Cheng, Wei Yue, Ying Xiao and 1 more

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Article in EMBO reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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11 authors.

Teng Wang *Department of Gynecology, the Second Affiliated Hospital; Centre for Biomedical Systems and Informatics, Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China.ORCID http://orcid.org/0009-0002-3975-2288

Mingyang Li *Department of Gynecology, the Second Affiliated Hospital; Centre for Biomedical Systems and Informatics, Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China.

Yimin Fu *Department of Gynecology, the Second Affiliated Hospital; Centre for Biomedical Systems and Informatics, Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China.

Minghao LiuDepartment of Gynecology, the Second Affiliated Hospital; Centre for Biomedical Systems and Informatics, Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China.

Yunkuan JiangDepartment of Gynecology, the Second Affiliated Hospital; Centre for Biomedical Systems and Informatics, Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China.ORCID http://orcid.org/0009-0005-5509-6649

Zhiwei JiangDepartment of Gynecology, the Second Affiliated Hospital; Centre for Biomedical Systems and Informatics, Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China.

Yuyan JiangDepartment of Gynecology, the Second Affiliated Hospital; Centre for Biomedical Systems and Informatics, Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China.

Zhuo ChengDepartment of Gynecology, the Second Affiliated Hospital; Centre for Biomedical Systems and Informatics, Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China.

Wei YueDepartment of Gynecology, the Second Affiliated Hospital; Centre for Biomedical Systems and Informatics, Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China.

Ying XiaoSir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China. xiaoying.srr@zju.edu.cn.ORCID http://orcid.org/0000-0002-3294-4407

Chaochen WangDepartment of Gynecology, the Second Affiliated Hospital; Centre for Biomedical Systems and Informatics, Zhejiang University-University of Edinburgh Institute, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, China. chaochenwang@intl.zju.edu.cn.ORCID http://orcid.org/0000-0003-2346-2884

Funding

MOST | National Key Research and Development Program of China (NKPs) 2021YFA1101100MOST | National Natural Science Foundation of China (NSFC) 31970776MOST | National Natural Science Foundation of China (NSFC) 32370872

6 · The paper itself

Abstract

Exocrine glands, despite varied secretory functions and locations, share similar structures and stem cell-dependent development and regeneration. However, the common stem cell regulatory mechanisms across these glands remain elusive. In this study, we integrate single-cell RNA sequencing datasets from mammary, salivary, and lacrimal glands across species and discover the specific enrichment of the long noncoding RNA Carmn in epithelial stem cell-enriched basal lineages. Functional studies demonstrate that Carmn regulates progenitor cell activity and the plasticity of basal cells in exocrine glands. In the mammary gland, Carmn regulates the Wnt/β-Catenin-driven stem cell program through an interaction with CTND1. Furthermore, Carmn is required for tumor formation by Wnt1-driven tumor stem cells. Together, these findings identify Carmn as a conserved regulator of epithelial basal-cell stemness in exocrine glands and as a facilitator of Wnt/β-catenin signaling.

Identifiers

PMID42850414

DOI10.1038/ncomms14049

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