Evidence map›Paper›PMID 42850386›Full record

ArticleJournal of cardiovascular translational research2026

α7-nAChR Activation is Associated with Attenuation of Cardiac Fibrosis in Ischemic Cardiomyopathy via SIRT3-Dependent Modulation of EndMT.

Ruilin He, Shujie Wu, Que Xu, Yifan Lin, Xiaohui Niu, Suwei Weng, Jiafeng Lin

Abstract read
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Article in Journal of cardiovascular translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ruilin HeDepartment of Cardiology, The Second Affiliated Hospital and Yuying, Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang Province, China.
Shujie WuDepartment of Cardiology, The Second Affiliated Hospital and Yuying, Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang Province, China.
Que XuDepartment of Cardiology, Jinhua People's Hospital, Jinhua, 321000, Zhejiang Province, China.
Yifan LinDepartment of Cardiology, The Third Affiliated Hospital of Wenzhou Medical University and Ruian People's Hospital, Wenzhou, 325000, Zhejiang Province, China.
Xiaohui NiuDepartment of Cardiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang Province, China.
Suwei WengTaishun People's Hospital, Wenzhou, 325000, Zhejiang Province, China.
Jiafeng LinDepartment of Cardiology, The Second Affiliated Hospital and Yuying, Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang Province, China. linjiafeng_wzmcfey@163.com.ORCID http://orcid.org/0000-0003-1748-7794

Funding

National Natural Science Foundation of China 82070333Natural Science Foundation of Zhejiang Province LY21H020011Wenzhou Municipal Science and Technology Bureau ZY2020018
6 · The paper itself

Abstract

To investigate whether α7-nicotinic acetylcholine receptor (α7-nAChR) activation attenuates ischemic cardiomyopathy (ICM) through regulation of endothelial-to-mesenchymal transition (EndMT), and to explore the involvement of Sirtuin-3 (SIRT3) in this process. ICM was induced in rats by coronary ligation for 4 weeks, followed by treatment with PNU-282,987, a selective α7-nAChR agonist, or cardiac-specific SIRT3 knockdown using serotype 9 adeno-associated virus (AAV9). Human umbilical vein endothelial cells (HUVECs) were treated with transforming growth factor-β (TGF-β) and/or PNU-282,987 (10 µM). α7-nAChR activation improved cardiac function, reversed ICM-induced TGF-β upregulation and SIRT3 downregulation, and inhibited EndMT-related changes. These effects were weakened by SIRT3 knockdown. The findings suggest that α7-nAChR activation alleviates ICM and myocardial fibrosis through a SIRT3-dependent mechanism, although direct receptor-level specificity requires further validation.

Indexed as

alpha7 Nicotinic Acetylcholine ReceptorBenzamidesBridged Bicyclo CompoundsCardiomyopathiesEndothelial-Mesenchymal TransitionHuman Umbilical Vein Endothelial CellsMyocardial IschemiaMyocardiumNicotinic AgonistsSirtuin 3AnimalsCells, CulturedDisease Models, AnimalFibrosisHumansMalealpha7 Nicotinic Acetylcholine ReceptorBenzamidesBridged Bicyclo CompoundsChrna7 protein, ratNicotinic AgonistsPNU-282987SIRT3 protein, humanSIRT3 protein, ratSirtuin 3SirtuinsTransforming Growth Factor betaCardiac fibrosisEndothelial-to-mesenchymal transitionIschemic cardiomyopathySirtuin-3α7-nicotinic acetylcholine receptor

Identifiers

PMID42850386

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.