ReviewPediatric research2026
Current perspectives and future horizons in predicting response to nutrition therapy in children with Crohn's disease - a narrative review.
Review in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exclusive enteral nutrition (EEN) and partial enteral nutrition (PEN) alongside Crohn's Disease Exclusion Diet (CDED) are evidence-based treatment strategies for children with Crohn's disease. However, the remission rates induced through nutritional therapy vary depending on the research design, treatment population, and outcome definition. The growing body of evidence highlights the necessity of a transitioning from "one-treatment-suits-all" strategy towards "tailor-made" precision-based therapeutic approach in children with Crohn's disease to obtain the optimal treatment response. Precise personalized therapeutic plan created on the patient's treatment-responsiveness phenotype prior to the treatment initiation appears to be an utmost need for children with Crohn's disease. A personalized approach to treatment has multiple benefits for individuals and the healthcare system. The identification of reliable predictors of treatment response is crucial for selecting the optimal therapy for individuals. In this review we aim to present a state-of-the-art summary of the current knowledge on predictive factors of response to nutrition therapy defined as EEN, and PEN with CDED in children with Crohn's disease. The exploration of treatment predictors may be a small but crucial step toward individualized therapeutic approach in this group of patients, potentially enabling the selection of the most appropriate therapy for each individual patient. IMPACT: This review synthetizes the current knowledge on predictive factors of a response to nutrition therapy in children with Crohn's disease. Early clinical improvement and reduction of faecal calprotectin are potential indicators of positive outcome of nutritional therapy in Crohn's disease. The anticipation of treatment response transcends patients' stratification based on clinical characteristics assemblages. Integration of clinical and multiomic data into a decision-making approach may facilitate personalized treatment in the future. However, current literature provides insufficient evidence for definitive predictors of response to nutritional therapy in Crohn's disease.
Identifiers
42850358What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.