Evidence map›Paper›PMID 42850337›Full record

ArticleJournal of molecular medicine (Berlin, Germany)2026

Copper-induced suppression of the PPARα-FABP1 axis sensitizes hepatocytes to ferroptosis in Wilson disease.

Yingjie Li, Yaoyi Wu, Yanwen Zhou, Liyan Zhao, Zhenyu Xu, Yimin Zhang, Ning Zhou

Abstract read
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Article in Journal of molecular medicine (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yingjie LiDepartment of Infectious Diseases, The Second Xiangya Hospital, Central South University, Changsha, China.
Yaoyi WuState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Hangzhou, China.
Yanwen ZhouDepartment of Infectious Diseases, The Second Xiangya Hospital, Central South University, Changsha, China.
Liyan ZhaoState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Hangzhou, China.
Zhenyu XuDepartment of Infectious Diseases, The Second Xiangya Hospital, Central South University, Changsha, China.
Yimin ZhangState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Hangzhou, China. 1307020@zju.edu.cn.
Ning ZhouDepartment of Infectious Diseases, The Second Xiangya Hospital, Central South University, Changsha, China. zhouning1@csu.edu.cn.ORCID http://orcid.org/0000-0003-2634-8761

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wilson disease (WD) is characterized by hepatic copper accumulation and progressive liver injury, yet the mechanisms linking copper overload to hepatocellular damage remain incompletely understood. Here, we identify suppression of the PPARα-FABP1 axis as a key metabolic vulnerability that sensitizes hepatocytes to ferroptosis in WD. Liver tissues from WD patients and Atp7b

Indexed as

CopperFatty Acid-Binding ProteinsFerroptosisHepatocytesHepatolenticular DegenerationPPAR alphaAnimalsHumansLipid PeroxidationLiverMaleMiceMice, KnockoutSignal TransductionCopperFABP1 protein, humanFabp1 protein, mouseFatty Acid-Binding ProteinsPPAR alphaCopper overloadFerroptosisLipid peroxidationPPARα–FABP1 axisWilson disease

Identifiers

PMID42850337

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.