ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026
Corneal clarity and biomechanical stability after mitomycin C-assisted photorefractive keratectomy in low, moderate, and high myopia.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo evaluate refractive, tomographic, densitometric, and biomechanical outcomes of photorefractive keratectomy (PRK) across different degrees of myopia.
methodsThis retrospective observational study was included eyes undergoing mitomycin C (MMC)-assisted PRK for myopia (with or without astigmatism) were categorized as low (spherical equivalent [SE] > -3.0 D), moderate (- 6.0 D < SE ≤ - 3.0 D), and high myopia (SE ≤ -6.0 D). Refractive, tomographic, densitometric, and biomechanical parameters were analyzed preoperatively and at 1, 6, and 12 months postoperatively.
results145 eyes were included: 50 low, 50 moderate, and 45 high myopia eyes. At 12 months, ≥ 93% of eyes in all groups achieved uncorrected distance visual acuity of 20/20 or better, with comparable efficacy and safety indices with no loss of corrected distance visual acuity. Postoperative SE within ± 0.50 D was achieved in 98%, 92%, and 91% of eyes in the low, moderate, and high myopia groups, respectively. Total anterior and total corneal densitometry decreased significantly from baseline in all groups (all p < 0.001), without intergroup differences. Biomechanical analysis showed significant postoperative increases in deformation amplitude ratio, integrated radius, and E-stage, and decreases in stiffness parameter A1, Ambrosio relational thickness to the horizontal profile, and Corvis biomechanical factor (all p < 0.001). However, these parameters remained stable during follow-up period, with no significant intergroup differences from 1 to 12 months. Mean CBI-LVC values remained below the 0.2 cut-off in all groups, and no ectasia developed.
conclusionMMC-assisted PRK demonstrated favorable 12-month refractive, visual, densitometric, and biomechanical outcomes across low, moderate, and high myopia groups, with comparable postoperative stability and no observed ectasia observed during the follow-up period.
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