Evidence map›Paper›PMID 42850295›Full record

ArticleCommunications biology2026

Expanded proinflammatory CD4 T cells expressing toll like receptor 4 in trauma associated acute lung injury.

Priyanka Hastak, Christopher R Andersen, Phoebe Crammond, Zong-Hong Zhang, Chansavath Phetsouphanh, David van Bockel, Calum Walsh, Louise M Judd, Timothy P Stinear, Aayushma Lohani and 10 more

Abstract read
PubMed Publisher
In one paragraph

Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Priyanka Hastak *Immunovirology and Pathogenesis Program, Kirby Institute, University of New South Wales, Sydney, NSW, Australia. phastak@kirby.unsw.edu.au.ORCID http://orcid.org/0000-0002-4851-3855
Christopher R Andersen *Immunovirology and Pathogenesis Program, Kirby Institute, University of New South Wales, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0002-9321-8660
Phoebe Crammond *Immunovirology and Pathogenesis Program, Kirby Institute, University of New South Wales, Sydney, NSW, Australia.ORCID http://orcid.org/0009-0006-5395-3296
Zong-Hong ZhangImmunovirology and Pathogenesis Program, Kirby Institute, University of New South Wales, Sydney, NSW, Australia.
Chansavath PhetsouphanhImmunovirology and Pathogenesis Program, Kirby Institute, University of New South Wales, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0001-6617-5995
David van BockelImmunovirology and Pathogenesis Program, Kirby Institute, University of New South Wales, Sydney, NSW, Australia.
Calum WalshDoherty Applied Microbial Genomics, Department of Microbiology & Immunology, Doherty Institute for Infection & Immunity, University of Melbourne, Melbourne, VIC, Australia.
Louise M JuddDoherty Applied Microbial Genomics, Department of Microbiology & Immunology, Doherty Institute for Infection & Immunity, University of Melbourne, Melbourne, VIC, Australia.
Timothy P StinearDoherty Applied Microbial Genomics, Department of Microbiology & Immunology, Doherty Institute for Infection & Immunity, University of Melbourne, Melbourne, VIC, Australia.ORCID http://orcid.org/0000-0003-0150-123X
Aayushma LohaniImmunovirology and Pathogenesis Program, Kirby Institute, University of New South Wales, Sydney, NSW, Australia.
Swosti ShresthaImmunovirology and Pathogenesis Program, Kirby Institute, University of New South Wales, Sydney, NSW, Australia.
Raymond LouieSchool of Computer Science and Engineering, University of New South Wales, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0002-9384-2447
Frances BassCritical Care and Trauma Division, The George Institute for Global Health, Sydney, NSW, Australia.
Anthony DelaneyIntensive Care Unit, Royal North Shore Hospital, Sydney, NSW, Australia.
Naomi HammondIntensive Care Unit, Royal North Shore Hospital, Sydney, NSW, Australia.
Balasubramanian VenkateshCritical Care and Trauma Division, The George Institute for Global Health, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0002-3234-5244
Simon FinferCritical Care and Trauma Division, The George Institute for Global Health, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0002-2785-5864
Nicodemus TedlaSchool of Biomedical Science, University of New South Wales, Sydney, NSW, Australia.
Anthony D KelleherImmunovirology and Pathogenesis Program, Kirby Institute, University of New South Wales, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0002-0009-3337
Sarah C SassonImmunovirology and Pathogenesis Program, Kirby Institute, University of New South Wales, Sydney, NSW, Australia. ssasson@kirby.unsw.edu.au.ORCID http://orcid.org/0000-0002-5329-9072

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute lung injury (ALI) is characterised by hypoxia and inflammation that derives from diverse aetiologies. Delineating the molecular pathogeneses may identify treatable subgroups and inform clinical trials. Using a multi-omics approach, we analysed trauma-associated ALI (n = 9), COVID-19 ALI (n = 11), ICU controls (n = 13) using scRNA-seq, serum cytokine profiling, and bronchoalveolar lavage (BAL) microbiome analysis. We identified a population of activated CD4

Indexed as

Acute Lung InjuryCD4-Positive T-LymphocytesToll-Like Receptor 4Wounds and InjuriesBronchoalveolar Lavage FluidCOVID-19CytokinesFemaleHumansInflammationMaleMicrobiotaSARS-CoV-2CytokinesTLR4 protein, humanToll-Like Receptor 4

Identifiers

PMID42850295

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.